Zika virus evolution and spread in the Americas
Author(s)Matranga, Christian B.; Wohl, Shirlee; Freije, Catherine A.; Winnicki, Sarah M.; West, Kendra; Baniecki, Mary Lynn; Gladden-Young, Adrianne; Lin, Aaron E.; Tomkins-Tinch, Christopher H.; Luo, Cynthia Y.; Shah, Rickey R.; Chak, Bridget; Barbosa-Lima, Giselle; Delatorre, Edson; Vieira, Yasmine R.; Paul, Lauren M.; Tan, Amanda L.; Barcellona, Carolyn M.; Porcelli, Mario C.; Vasquez, Chalmers; Cannons, Andrew C.; Cone, Marshall R.; Hogan, Kelly N.; Kopp, Edgar W.; Anzinger, Joshua J.; Garcia, Kimberly F.; Parham, Leda A.; Ramírez, Rosa M. Gélvez; Montoya, Maria C. Miranda; Rojas, Diana P.; Brown, Catherine M.; Hennigan, Scott; Sabina, Brandon; Scotland, Sarah; Gangavarapu, Karthik; Grubaugh, Nathan D.; Oliveira, Glenn; Robles-Sikisaka, Refugio; Rambaut, Andrew; Smole, Sandra; Halloran, M. Elizabeth; Villar, Luis; Mattar, Salim; Lorenzana, Ivette; Cerbino-Neto, Jose; Valim, Clarissa; Degrave, Wim; Bozza, Patricia T.; Isern, Sharon; Michael, Scott F.; Bozza, Fernando A.; Souza, Thiago M. L.; Yozwiak, Nathan L.; MacInnis, Bronwyn L.; Sabeti, Pardis C.; Metsky, Hayden C.; Schaffner, Stephen F; Quigley, James Edwin; Ye, Simon Huang; Park, Daniel; Barnes, Kayla; Gehrke, Lee; Gnirke, Andreas; Andersen, Kristian; Bosch, Irene; ... Show more Show less
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Although the recent Zika virus (ZIKV) epidemic in the Americas and its link to birth defects have attracted a great deal of attention1,2, much remains unknown about ZIKV disease epidemiology and ZIKV evolution, in part owing to a lack of genomic data. Here we address this gap in knowledge by using multiple sequencing approaches to generate 110 ZIKV genomes from clinical and mosquito samples from 10 countries and territories, greatly expanding the observed viral genetic diversity from this outbreak. We analysed the timing and patterns of introductions into distinct geographic regions; our phylogenetic evidence suggests rapid expansion of the outbreak in Brazil and multiple introductions of outbreak strains into Puerto Rico, Honduras, Colombia, other Caribbean islands, and the continental United States. We find that ZIKV circulated undetected in multiple regions for many months before the first locally transmitted cases were confirmed, highlighting the importance of surveillance of viral infections. We identify mutations with possible functional implications for ZIKV biology and pathogenesis, as well as those that might be relevant to the effectiveness of diagnostic tests.
DepartmentInstitute for Medical Engineering and Science; Broad Institute of MIT and Harvard; Harvard University--MIT Division of Health Sciences and Technology; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science; Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science
Nature Publishing Group
Metsky, Hayden C. et al. “Zika Virus Evolution and Spread in the Americas.” Nature 546, 7658 (May 2017): 411–415 © 2017 Macmillan Publishers Limited, part of Springer Nature
Author's final manuscript