The 3D Genome as Moderator of Chromosomal Communication
Author(s)Dekker, Job; Mirny, Leonid A
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Proper expression of genes requires communication with their regulatory elements that can be located elsewhere along the chromosome. The physics of chromatin fibers imposes a range of constraints on such communication. The molecular and biophysical mechanisms by which chromosomal communication is established, or prevented, have become a topic of intense study, and important roles for the spatial organization of chromosomes are being discovered. Here we present a view of the interphase 3D genome characterized by extensive physical compartmentalization and insulation on the one hand and facilitated long-range interactions on the other. We propose the existence of topological machines dedicated to set up and to exploit a 3D genome organization to both promote and censor communication along and between chromosomes.
DepartmentInstitute for Medical Engineering and Science; Massachusetts Institute of Technology. Department of Physics
Dekker, Job, and Mirny, Leonid. “The 3D Genome as Moderator of Chromosomal Communication.” Cell 164, 6 (March 2016): 1110–1121 © 2016 Elsevier Inc
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