| dc.contributor.author | Imakaev, Maksim Viktorovich | |
| dc.contributor.author | Fudenberg, Geoffrey | |
| dc.contributor.author | Mirny, Leonid A | |
| dc.date.accessioned | 2017-12-19T14:38:30Z | |
| dc.date.available | 2017-12-19T14:38:30Z | |
| dc.date.issued | 2015-09 | |
| dc.date.submitted | 2015-09 | |
| dc.identifier.issn | 0014-5793 | |
| dc.identifier.issn | 1873-3468 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/112798 | |
| dc.description.abstract | Recently, Chromosome Conformation Capture (3C) based experiments have highlighted the importance of computational models for the study of chromosome organization. In this review, we propose that current computational models can be grouped into roughly four classes, with two classes of data-driven models: consensus structures and data-driven ensembles, and two classes of de novo models: structural ensembles and mechanistic ensembles. Finally, we highlight specific questions mechanistic ensembles can address. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R01HG003143) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R01 GM114190) | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/J.FEBSLET.2015.09.004 | en_US |
| dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Modeling chromosomes: Beyond pretty pictures | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Imakaev, Maxim V. et al. “Modeling Chromosomes: Beyond Pretty Pictures.” FEBS Letters 589, 20 (September 2015): 3031–3036 © 2015 Federation of European Biochemical Societies | en_US |
| dc.contributor.department | Institute for Medical Engineering and Science | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Physics | en_US |
| dc.contributor.mitauthor | Imakaev, Maksim Viktorovich | |
| dc.contributor.mitauthor | Fudenberg, Geoffrey | |
| dc.contributor.mitauthor | Mirny, Leonid A | |
| dc.relation.journal | FEBS Letters | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2017-12-18T20:46:11Z | |
| dspace.orderedauthors | Imakaev, Maxim V.; Fudenberg, Geoffrey; Mirny, Leonid A. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-5320-2728 | |
| dc.identifier.orcid | https://orcid.org/0000-0001-5905-6517 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-0785-5410 | |
| mit.license | OPEN_ACCESS_POLICY | en_US |
