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Association of hypermagnesemia and blood pressure in the critically ill

Author(s)
Nelson, Rachel; Alper, Seth L.; Mukamal, Kenneth J.; Danziger, John; Scott, Daniel; Celi, Leo Anthony G.; Lee, Joonwu; Mark, Roger G; ... Show more Show less
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Abstract
BACKGROUND: Although magnesium is important in the biology of blood pressure regulation, little clinical data exist on the association of hypermagnesemia and blood pressure. METHOD:: We examined the association of hypermagnesemia and SBP in a cross-sectional study of 10 521 ICU patients from a single tertiary care medical center, 6% of whom had a serum magnesium above 2.6 mg/dl at time of admission. RESULTS:: In a multivariable analysis, hypermagnesemia was associated with SBP 6.2 mmHg lower [95% confidence interval (CI) -8.2, -4.2, P < 0.001] than in patients with admission values of serum magnesium 2.6 mg/dl or less. Each mg/dl increase in serum magnesium was associated with a decrease in SBP of 4.3 mmHg (95% CI -5.5, -3.1, P < 0.001). In addition, hypermagnesemic patients had a 2.48-fold greater likelihood (95% CI 2.06, 3.00, P < 0.001) of receiving intravenous vasopressors during the first 24h of ICU care, independent of admission SBP. CONCLUSION:: Our findings add support to the biologic importance of magnesium regulation in blood pressure control.
Date issued
2013-11
URI
http://hdl.handle.net/1721.1/112814
Department
Massachusetts Institute of Technology. Institute for Medical Engineering & Science; Harvard University--MIT Division of Health Sciences and Technology
Journal
Journal of Hypertension
Publisher
Wolters Kluwer - Lippincott Williams & Wilkins
Citation
Celi, Leo A. et al. “Association of Hypermagnesemia and Blood Pressure in the Critically Ill.” Journal of Hypertension 31, 11 (November 2013): 2136–2141. © 2013 Wolters Kluwer Health Lippincott Williams & Wilkins
Version: Author's final manuscript
ISSN
0263-6352

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