| dc.contributor.author | Bandar, Jeffrey | |
| dc.contributor.author | Ascic, Erhad | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2018-01-10T15:24:08Z | |
| dc.date.available | 2018-01-10T15:24:08Z | |
| dc.date.issued | 2017-04 | |
| dc.date.submitted | 2016-03 | |
| dc.identifier.issn | 0002-7863 | |
| dc.identifier.issn | 1520-5126 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/113034 | |
| dc.description.abstract | A new method for the enantioselective reductive coupling of aryl alkenes with activated carboxylic acid derivatives via copper hydride catalysis is described. Dual catalytic cycles are proposed, with a relatively fast enantioselective hydroacylation cycle followed by a slower diastereoselective ketone reduction cycle. Symmetrical aryl carboxyclic anhydrides provide access to enantioenriched α-substituted ketones or alcohols with excellent stereoselectivity and functional group tolerance. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant GM46059) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant GM112197) | en_US |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/JACS.6B03086 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | ACS | en_US |
| dc.title | Enantioselective CuH-Catalyzed Reductive Coupling of Aryl Alkenes and Activated Carboxylic Acids | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Bandar, Jeffrey S. et al. “Enantioselective CuH-Catalyzed Reductive Coupling of Aryl Alkenes and Activated Carboxylic Acids.” Journal of the American Chemical Society 138, 18 (April 2016): 5821–5824 © 2016 American Chemical Society | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Bandar, Jeffrey | |
| dc.contributor.mitauthor | Ascic, Erhad | |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | |
| dc.relation.journal | Journal of the American Chemical Society | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2018-01-09T19:21:22Z | |
| dspace.orderedauthors | Bandar, Jeffrey S.; Ascic, Erhad; Buchwald, Stephen L. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-5418-3082 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | PUBLISHER_POLICY | en_US |
