| dc.contributor.author | Gribble, Michael William | |
| dc.contributor.author | Pirnot, Michael T | |
| dc.contributor.author | Bandar, Jeffrey | |
| dc.contributor.author | Liu, Richard | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2018-01-10T15:41:53Z | |
| dc.date.available | 2018-01-10T15:41:53Z | |
| dc.date.issued | 2017-01 | |
| dc.date.submitted | 2016-12 | |
| dc.identifier.issn | 0002-7863 | |
| dc.identifier.issn | 1520-5126 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/113039 | |
| dc.description.abstract | We report a highly enantioselective CuH-catalyzed Markovnikov hydrosilylation of vinylarenes and vinyl heterocycles. This method has a broad scope and enables both the synthesis of isolable silanes and the conversion of crude products to chiral alcohols. Density functional theory calculations support a mechanism proceeding by hydrocupration followed by σ-bond metathesis with a hydrosilane. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Award GM46059) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Postdoctoral Fellowship 1F32GM113311) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Postdoctoral Fellowship GM112197) | en_US |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/JACS.6B13029 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | ACS | en_US |
| dc.title | Asymmetric Copper Hydride-Catalyzed Markovnikov Hydrosilylation of Vinylarenes and Vinyl Heterocycles | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Gribble, Michael W., et al. “Asymmetric Copper Hydride-Catalyzed Markovnikov Hydrosilylation of Vinylarenes and Vinyl Heterocycles.” Journal of the American Chemical Society, vol. 139, no. 6, Feb. 2017, pp. 2192–95. © 2017 American Chemical Society. | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Gribble, Michael William | |
| dc.contributor.mitauthor | Pirnot, Michael T | |
| dc.contributor.mitauthor | Bandar, Jeffrey | |
| dc.contributor.mitauthor | Liu, Richard | |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | |
| dc.relation.journal | Journal of the American Chemical Society | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2018-01-09T18:43:28Z | |
| dspace.orderedauthors | Gribble, Michael W.; Pirnot, Michael T.; Bandar, Jeffrey S.; Liu, Richard Y.; Buchwald, Stephen L. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0003-2008-3264 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-7896-1683 | |
| dc.identifier.orcid | https://orcid.org/0000-0001-5418-3082 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | PUBLISHER_POLICY | en_US |
