| dc.contributor.author | Friis, Stig During | |
| dc.contributor.author | Pirnot, Michael T | |
| dc.contributor.author | Buchwald, Stephen Leffler | |
| dc.date.accessioned | 2018-01-10T21:26:47Z | |
| dc.date.available | 2018-01-10T21:26:47Z | |
| dc.date.issued | 2016-06 | |
| dc.date.submitted | 2016-05 | |
| dc.identifier.issn | 0002-7863 | |
| dc.identifier.issn | 1520-5126 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/113058 | |
| dc.description.abstract | Detailed in this Communication is the enantioselective synthesis of 1,1-diarylalkanes, a structure found in a range of pharmaceutical drug agents and natural products, through the employment of copper(I) hydride and palladium catalysis. Judicious choice of ligand for both Cu and Pd enabled this hydroarylation protocol to work for an extensive array of aryl bromides and styrenes, including β-substituted vinylarenes and six-membered heterocycles, under relatively mild conditions. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Award GM46059) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Award GM058160-17S1) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Award 1F32GM113311) | en_US |
| dc.publisher | American Chemical Society (ACS) | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1021/JACS.6B04566 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | ACS | en_US |
| dc.title | Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Friis, Stig D., Michael T. Pirnot, and Buchwald, Stephen L. “Asymmetric Hydroarylation of Vinylarenes Using a Synergistic Combination of CuH and Pd Catalysis.” Journal of the American Chemical Society 138, 27 (July 2016): 8372–8375 © 2016 American Chemical Society | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemistry | en_US |
| dc.contributor.mitauthor | Friis, Stig During | |
| dc.contributor.mitauthor | Pirnot, Michael T | |
| dc.contributor.mitauthor | Buchwald, Stephen Leffler | |
| dc.relation.journal | Journal of the American Chemical Society | en_US |
| dc.eprint.version | Final published version | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2018-01-10T16:08:29Z | |
| dspace.orderedauthors | Friis, Stig D.; Pirnot, Michael T.; Buchwald, Stephen L. | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-2624-915X | |
| dc.identifier.orcid | https://orcid.org/0000-0002-7896-1683 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-3875-4775 | |
| mit.license | PUBLISHER_POLICY | en_US |
