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Enantioselective Synthesis of Carbo- and Heterocycles through a CuH-Catalyzed Hydroalkylation Approach

dc.contributor.authorWang, Yiming
dc.contributor.authorBruno, Nicholas Charles
dc.contributor.authorPlaceres, Angel L
dc.contributor.authorZhu, Shaolin
dc.contributor.authorBuchwald, Stephen Leffler
dc.date.accessioned2018-01-11T14:38:05Z
dc.date.available2018-01-11T14:38:05Z
dc.date.issued2015-08
dc.date.submitted2015-07
dc.identifier.issn0002-7863
dc.identifier.issn1520-5126
dc.identifier.urihttp://hdl.handle.net/1721.1/113059
dc.description.abstractThe enantioselective, intramolecular hydroalkylation of halide-tethered styrenes has been achieved through a copper hydride-catalyzed process. This approach allowed for the synthesis of enantioenriched cyclobutanes, cyclopentanes, indanes, and six-membered N- and O-heterocycles. This protocol was applied to the synthesis of the commercial serotonin reuptake inhibitor (-)-paroxetine.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Award GM46059)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Award GM112218)en_US
dc.publisherAmerican Chemical Society (ACS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1021/JACS.5B07061en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceACSen_US
dc.titleEnantioselective Synthesis of Carbo- and Heterocycles through a CuH-Catalyzed Hydroalkylation Approachen_US
dc.typeArticleen_US
dc.identifier.citationWang, Yi-Ming et al. “Enantioselective Synthesis of Carbo- and Heterocycles through a CuH-Catalyzed Hydroalkylation Approach.” Journal of the American Chemical Society 137, 33 (August 2015): 10524–10527 © 2015 American Chemical Societyen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorWang, Yiming
dc.contributor.mitauthorBruno, Nicholas Charles
dc.contributor.mitauthorPlaceres, Angel L
dc.contributor.mitauthorZhu, Shaolin
dc.contributor.mitauthorBuchwald, Stephen Leffler
dc.relation.journalJournal of the American Chemical Societyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-01-10T16:28:29Z
dspace.orderedauthorsWang, Yi-Ming; Bruno, Nicholas C.; Placeres, Ángel L.; Zhu, Shaolin; Buchwald, Stephen L.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0001-6414-0908
dc.identifier.orcidhttps://orcid.org/0000-0003-3875-4775
mit.licensePUBLISHER_POLICYen_US


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