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dc.contributor.authorCorcoran, Emily B.
dc.contributor.authorLin, Shishi
dc.contributor.authorDreher, Spencer D.
dc.contributor.authorDiRocco, Daniel A.
dc.contributor.authorDavies, Ian W.
dc.contributor.authorMacMillan, David W. C.
dc.contributor.authorPirnot, Michael T
dc.contributor.authorBuchwald, Stephen Leffler
dc.date.accessioned2018-01-11T14:45:51Z
dc.date.available2018-01-11T14:45:51Z
dc.date.issued2016-07
dc.date.submitted2016-04
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/1721.1/113060
dc.description.abstractOver the past two decades, there have been major developments in transition metal-catalyzed aminations of aryl halides to form anilines, a common structure found in drug agents, natural product isolates, and fine chemicals. Many of these approaches have enabled highly efficient and selective coupling through the design of specialized ligands, which facilitate reductive elimination from a destabilized metal center. We postulated that a general and complementary method for carbon-nitrogen bond formation could be developed through the destabilization of a metal amido complex via photoredox catalysis, thus providing an alternative approach to the use of structurally complex ligand systems. Here, we report the development of a distinct mechanistic paradigm for aryl amination using ligand-free nickel(II) salts, in which facile reductive elimination from the nickel metal center is induced via a photoredox-catalyzed electron-transfer event.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Award GM58160)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Award RO1-GM078201-05)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Award GM113311)en_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/SCIENCE.AAG0209en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleAryl amination using ligand-free Ni(II) salts and photoredox catalysisen_US
dc.typeArticleen_US
dc.identifier.citationCorcoran, Emily B. et al. “Aryl Amination Using Ligand-Free Ni(II) Salts and Photoredox Catalysis.” Science 353, 6296 (June 2016): 279–283 © 2016 American Association for the Advancement of Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.mitauthorPirnot, Michael T
dc.contributor.mitauthorBuchwald, Stephen Leffler
dc.relation.journalScienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-01-10T16:11:18Z
dspace.orderedauthorsCorcoran, Emily B.; Pirnot, Michael T.; Lin, Shishi; Dreher, Spencer D.; DiRocco, Daniel A.; Davies, Ian W.; Buchwald, Stephen L.; MacMillan, David W. C.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7896-1683
dc.identifier.orcidhttps://orcid.org/0000-0003-3875-4775
mit.licenseOPEN_ACCESS_POLICYen_US


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