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dc.contributor.authorMohanraju, Prarthana
dc.contributor.authorMakarova, Kira S.
dc.contributor.authorKoonin, Eugene V.
dc.contributor.authorvan der Oost, John
dc.contributor.authorZetsche, Bernd
dc.contributor.authorZhang, Feng
dc.date.accessioned2018-01-16T15:33:39Z
dc.date.available2018-01-16T15:33:39Z
dc.date.issued2016-08
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/1721.1/113195
dc.description.abstractAdaptive immunity had been long thought of as an exclusive feature of animals. However, the discovery of the CRISPR-Cas defense system, present in almost half of prokaryotic genomes, proves otherwise. Because of the everlasting parasite-host arms race, CRISPR-Cas has rapidly evolved through horizontal transfer of complete loci or individual modules, resulting in extreme structural and functional diversity. CRISPR-Cas systems are divided into two distinct classes that each consist of three types and multiple subtypes. We discuss recent advances in CRISPR-Cas research that reveal elaborate molecular mechanisms and provide for a plausible scenario of CRISPR-Cas evolution. We also briefly describe the latest developments of a wide range of CRISPR-based applications.en_US
dc.language.isoen_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/science.aad5147en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceProf. Zhang via Courtney Crummetten_US
dc.titleDiverse evolutionary roots and mechanistic variations of the CRISPR-Cas systemsen_US
dc.typeArticleen_US
dc.identifier.citationMohanraju, Prarthana et al. “Diverse Evolutionary Roots and Mechanistic Variations of the CRISPR-Cas Systems.” Science 353, 6299 (August 2016): aad5147 © 2016 American Association for the Advancement of Scienceen_US
dc.contributor.departmentBroad Institute of MIT and Harvarden_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.approverZhang, Fengen_US
dc.contributor.mitauthorZetsche, Bernd
dc.contributor.mitauthorZhang, Feng
dc.relation.journalScienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsMohanraju, Prarthana; Makarova, Kira S.; Zetsche, Bernd; Zhang, Feng; Koonin, Eugene V.; van der Oost, Johnen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-2782-2509
mit.licenseOPEN_ACCESS_POLICYen_US


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