dc.contributor.author | Mohanraju, Prarthana | |
dc.contributor.author | Makarova, Kira S. | |
dc.contributor.author | Koonin, Eugene V. | |
dc.contributor.author | van der Oost, John | |
dc.contributor.author | Zetsche, Bernd | |
dc.contributor.author | Zhang, Feng | |
dc.date.accessioned | 2018-01-16T15:33:39Z | |
dc.date.available | 2018-01-16T15:33:39Z | |
dc.date.issued | 2016-08 | |
dc.identifier.issn | 0036-8075 | |
dc.identifier.issn | 1095-9203 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/113195 | |
dc.description.abstract | Adaptive immunity had been long thought of as an exclusive feature of animals. However, the discovery of the CRISPR-Cas defense system, present in almost half of prokaryotic genomes, proves otherwise. Because of the everlasting parasite-host arms race, CRISPR-Cas has rapidly evolved through horizontal transfer of complete loci or individual modules, resulting in extreme structural and functional diversity. CRISPR-Cas systems are divided into two distinct classes that each consist of three types and multiple subtypes. We discuss recent advances in CRISPR-Cas research that reveal elaborate molecular mechanisms and provide for a plausible scenario of CRISPR-Cas evolution. We also briefly describe the latest developments of a wide range of CRISPR-based applications. | en_US |
dc.language.iso | en_US | |
dc.publisher | American Association for the Advancement of Science (AAAS) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1126/science.aad5147 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | Prof. Zhang via Courtney Crummett | en_US |
dc.title | Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Mohanraju, Prarthana et al. “Diverse Evolutionary Roots and Mechanistic Variations of the CRISPR-Cas Systems.” Science 353, 6299 (August 2016): aad5147 © 2016 American Association for the Advancement of Science | en_US |
dc.contributor.department | Broad Institute of MIT and Harvard | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.approver | Zhang, Feng | en_US |
dc.contributor.mitauthor | Zetsche, Bernd | |
dc.contributor.mitauthor | Zhang, Feng | |
dc.relation.journal | Science | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Mohanraju, Prarthana; Makarova, Kira S.; Zetsche, Bernd; Zhang, Feng; Koonin, Eugene V.; van der Oost, John | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-2782-2509 | |
mit.license | OPEN_ACCESS_POLICY | en_US |