Microfluidics: A New Tool for Modeling Cancer–Immune Interactions
Author(s)
Wong, Siew Cheng; Boussommier, Alexandra; Li, Ran; Chen, Michelle B; Kamm, Roger Dale
DownloadKamm_Microfluidics.pdf (1.093Mb)
PUBLISHER_CC
Publisher with Creative Commons License
Creative Commons Attribution
Terms of use
Metadata
Show full item recordAbstract
In recognition of the enormous potential of immunotherapies against cancer, research into the interactions between tumor and immune cells has accelerated, leading to the recent FDA approval of several drugs that reduce cancer progression. Numerous cellular and molecular interactions have been identified by which immune cells can intervene in the metastatic cascade, leading to the development of several in vivo and in vitro model systems that can recapitulate these processes. Among these, microfluidic technologies hold many advantages in terms of their unique ability to capture the essential features of multiple cell type interactions in three-dimensions while allowing tight control of the microenvironment and real-time monitoring. Here, we review current assays and discuss the development of new microfluidic technologies for immunotherapy. Keywords
microfluidics
immunotherapy
metastatic cancer
drug screening
Date issued
2016-01Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Mechanical EngineeringJournal
Trends in Cancer
Publisher
Elsevier
Citation
Boussommier-Calleja, Alexandra et al. “Microfluidics: A New Tool for Modeling Cancer–Immune Interactions.” Trends in Cancer 2, 1 (January 2016): 6–19 © 2015 Elsevier Inc
Version: Author's final manuscript
ISSN
2405-8033