A family of cis-macrocyclic diphosphines: modular, stereoselective synthesis and application in catalytic CO₂/ethylene Coupling
Author(s)Beetstra, Dirk; Al-Nezari, Abdulaziz; Al-Bahily, Khalid; Knopf, Ioana; Tofan, Daniel; Cummins, Christopher C; ... Show more Show less
MetadataShow full item record
A family of cis-macrocyclic diphosphines was prepared in just three steps from white phosphorus and commercial materials using a modular synthetic approach. Alkylation of bicyclic diphosphane 3,4,8,9-tetramethyl-1,6-diphosphabicyclo(4.4.0)deca-3,8-diene, or P₂(dmb)₂ , produced phosphino-phosphonium salts [R-P₂(dmb)₂]X, where R is methyl, benzyl and isobutyl, in yields of 90-96%. Treatment of these salts with organolithium or Grignard reagents yielded symmetric and unsymmetric macrocyclic diphosphines of the form cis-1-R-6-R′-3,4,8,9-tetramethyl-2,5,7,10-tetrahydro-1,6-DiPhospheCine, or R,R′-DPC, in which R′ is methyl, cyclohexyl, phenyl or mesityl, in yields of 46-94%. Alternatively, symmetric diphosphine Cy₂-DPC was synthesized in 74% yield from the dichlorodiphosphine Cl₂P₂(dmb)₂. As a first application, these cis-macrocyclic diphosphines were used as ligands in the nickel-catalyzed synthesis of acrylate from CO₂ and ethylene, for which they showed promising catalytic activity.
DepartmentMassachusetts Institute of Technology. Department of Chemistry
Royal Society of Chemistry (RSC)
Knopf, Ioana et al. “A family of cis-macrocyclic diphosphines: modular, stereoselective synthesis and application in catalytic CO₂/ethylene Coupling.” Chemical Science 8, 2 (2017): 1463–1468 © 2017 The Royal Society of Chemistry.
Final published version