MIT Libraries homeMIT Libraries logoDSpace@MIT

MIT
View Item 
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
  • DSpace@MIT Home
  • MIT Open Access Articles
  • MIT Open Access Articles
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant

Author(s)
Lakerveld, Richard; Benyahia, Brahim; Heider, Patrick Louis; Zhang, Haitao; Braatz, Richard D; Barton, Paul I; ... Show more Show less
Thumbnail
Downloadprocesses-01-00330.pdf (2.628Mb)
PUBLISHER_CC

Publisher with Creative Commons License

Creative Commons Attribution

Terms of use
Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/
Metadata
Show full item record
Abstract
The judicious use of buffering capacity is important in the development of future continuous pharmaceutical manufacturing processes. The potential benefits are investigated of using optimal-averaging level control for tanks that have buffering capacity for a section of a continuous pharmaceutical pilot plant involving two crystallizers, a combined filtration and washing stage and a buffer tank. A closed-loop dynamic model is utilized to represent the experimental operation, with the relevant model parameters and initial conditions estimated from experimental data that contained a significant disturbance and a change in setpoint of a concentration control loop. The performance of conventional proportional-integral (PI) level controllers is compared with optimal-averaging level controllers. The aim is to reduce the production of off-spec material in a tubular reactor by minimizing the variations in the outlet flow rate of its upstream buffer tank. The results show a distinct difference in behavior, with the optimal-averaging level controllers strongly outperforming the PI controllers. In general, the results stress the importance of dynamic process modeling for the design of future continuous pharmaceutical processes. Keywords: control; process modeling; process simulation; parameter estimation; dynamic modeling; optimization; crystallization; continuous pharmaceutical manufacturing
Date issued
2013-11
URI
http://hdl.handle.net/1721.1/113335
Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Journal
Processes
Publisher
Multidisciplinary Digital Publishing Institute
Citation
Lakerveld, Richard et al. "Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant." Processes 1, 3 (November 2013): 330-348 © 2013 The Author(s)
Version: Final published version
ISSN
2227-9717

Collections
  • MIT Open Access Articles

Browse

All of DSpaceCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsThis CollectionBy Issue DateAuthorsTitlesSubjects

My Account

Login

Statistics

OA StatisticsStatistics by CountryStatistics by Department
MIT Libraries homeMIT Libraries logo

Find us on

Twitter Facebook Instagram YouTube RSS

MIT Libraries navigation

SearchHours & locationsBorrow & requestResearch supportAbout us
PrivacyPermissionsAccessibility
MIT
Massachusetts Institute of Technology
Content created by the MIT Libraries, CC BY-NC unless otherwise noted. Notify us about copyright concerns.