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Intra-chain organisation of hydrophobic residues controls inter-chain aggregation rates of amphiphilic polymers

Author(s)
Varilly, Patrick; Willard, Adam P.; Kirkegaard, Julius B.; Knowles, Tuomas P. J.; Chandler, David
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Abstract
Aggregation of amphiphiles through the action of hydrophobic interactions is a common feature in soft condensed matter systems and is of particular importance in the context of biophysics as it underlies both the generation of functional biological machinery as well as the formation of pathological misassembled states of proteins. Here we explore the aggregation behaviour of amphiphilic polymers using lattice Monte Carlo calculations and show that the distribution of hydrophobic residues within the polymer sequence determines the facility with which dry/wet interfaces can be created and that such interfaces drive the aggregation process.
Date issued
2017-04
URI
http://hdl.handle.net/1721.1/113639
Department
Massachusetts Institute of Technology. Department of Chemistry
Journal
The Journal of Chemical Physics
Publisher
American Institute of Physics (AIP)
Citation
Varilly, Patrick et al. “Intra-Chain Organisation of Hydrophobic Residues Controls Inter-Chain Aggregation Rates of Amphiphilic Polymers.” The Journal of Chemical Physics 146, 13 (April 2017): 135102 © 2017 Author(s)
Version: Original manuscript
ISSN
0021-9606
1089-7690

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