Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes
Author(s)
Wang, Bo; Lucy, Katie A.; Schuman, Joel S.; Ishikawa, Hiroshi; Bilonick, Richard A.; Sigal, Ian A.; Kagemann, Larry; Wollstein, Gadi; Lu, Chen David; Fujimoto, James G; ... Show more Show less
Downloads41598-017-10042-5.pdf (1.384Mb)
PUBLISHER_POLICY
Publisher Policy
Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.
Terms of use
Metadata
Show full item recordAbstract
Glaucoma is a leading cause of blindness that leads to characteristic changes in the optic nerve head (ONH) region, such as nasalization of vessels. It is unknown whether the spatial location of this vessel shift inside the ONH occurs within the lamina cribrosa (LC) or the prelaminar tissue. The purpose of this study was to compare the location of the central retinal vessel trunk (CRVT) in the LC and prelaminar tissue in living healthy and glaucomatous eyes. We acquired 3-dimensional ONH scans from 119 eyes (40 healthy, 29 glaucoma suspect, and 50 glaucoma) using optical coherence tomography (OCT). The CRVT location was manually delineated in separate projection images of the LC and prelamina. We found that the CRVT in glaucoma suspect and glaucomatous eyes was located significantly more nasally compared to healthy eyes at the level of the prelamina. There was no detectable difference found in the location of the CRVT at the level of the LC between diagnostic groups. While the nasal location of the CRVT in the prelamina has been associated with glaucomatous axonal death, our results suggest that the CRVT in the LC is anchored in the tissue with minimal variation in glaucomatous eyes.
Date issued
2017-08Department
Massachusetts Institute of Technology. Department of Electrical Engineering and Computer ScienceJournal
Scientific Reports
Publisher
Nature Publishing Group
Citation
Wang, Bo et al. “Location of the Central Retinal Vessel Trunk in the Laminar and Prelaminar Tissue of Healthy and Glaucomatous Eyes.” Scientific Reports 7, 1 (August 2017): 9930 © 2017 The Author(s)
Version: Final published version
ISSN
2045-2322