A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow
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A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow.pdf
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889.75 KB
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Author(s)
Lin, Hongkun
Dai, Chunhui
Jamison, Timothy F
Jensen, Klavs F
Date Issued
July 2017
Journal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Lin, Hongkun et al. “A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow.” Angewandte Chemie International Edition 56, 30 (June 2017): 8870–8873 © 2017 Wiley‐VCH Verlag GmbH & Co
Version
Author's final manuscript
Abstract
Within a total residence time of 9 min, the sodium salt of ciprofloxacin was prepared from simple building blocks via a linear sequence of six chemical reactions in five flow reactors. Sequential offline acidifications and filtrations afforded ciprofloxacin and ciprofloxacin hydrochloride. The overall yield of the eight‐step sequence was 60 %. No separation of intermediates was required throughout the synthesis when a single acylation reaction was applied to remove the main byproduct, dimethylamine.
MIT Department
Massachusetts Institute of Technology. Department of Chemical Engineering
Massachusetts Institute of Technology. Department of Chemistry
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Creative Commons Attribution-Noncommercial-Share Alike
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DOI of Published Version
https://doi.org/10.1002/anie.201703812
