A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow
Author(s)
Lin, Hongkun; Dai, Chunhui; Jamison, Timothy F; Jensen, Klavs F
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Within a total residence time of 9 min, the sodium salt of ciprofloxacin was prepared from simple building blocks via a linear sequence of six chemical reactions in five flow reactors. Sequential offline acidifications and filtrations afforded ciprofloxacin and ciprofloxacin hydrochloride. The overall yield of the eight‐step sequence was 60 %. No separation of intermediates was required throughout the synthesis when a single acylation reaction was applied to remove the main byproduct, dimethylamine.
Date issued
2017-07Department
Massachusetts Institute of Technology. Department of Chemical Engineering; Massachusetts Institute of Technology. Department of ChemistryJournal
Angewandte Chemie International Edition
Publisher
Wiley Blackwell
Citation
Lin, Hongkun et al. “A Rapid Total Synthesis of Ciprofloxacin Hydrochloride in Continuous Flow.” Angewandte Chemie International Edition 56, 30 (June 2017): 8870–8873 © 2017 Wiley‐VCH Verlag GmbH & Co
Version: Author's final manuscript
ISSN
1433-7851
1521-3773