Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala
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Beyeler, Anna; Chang, Chia-Jung; Silvestre, Margaux; Leveque, Clementine; Namburi, Praneeth; Wildes, Craig P; Tye, Kay M; ... Show more Show less
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The basolateral amygdala (BLA) mediates associative learning for both fear and reward. Accumulating evidence supports the notion that different BLA projections distinctly alter motivated behavior, including projections to the nucleus accumbens (NAc), medial aspect of the central amygdala (CeM), and ventral hippocampus (vHPC). Although there is consensus regarding the existence of distinct subsets of BLA neurons encoding positive or negative valence, controversy remains regarding the anatomical arrangement of these populations. First, we map the location of more than 1,000 neurons distributed across the BLA and recorded during a Pavlovian discrimination task. Next, we determine the location of projection-defined neurons labeled with retrograde tracers and use CLARITY to reveal the axonal path in 3-dimensional space. Finally, we examine the local influence of each projection-defined populations within the BLA. Understanding the functional and topographical organization of circuits underlying valence assignment could reveal fundamental principles about emotional processing. Basolateral amygdala (BLA) neurons distinctly encode cues predicting rewards or punishments, but how does form give rise to function? Beyeler et al. overlay anatomical projection target, location of neurons in a 3D map, and encoding properties during cue discrimination. The influence on local networks differs across projection-defined BLA populations. Keywords: reward; aversion; topography; tracing; connectivity; network; channelrhodopsin; phototagging; photoexcitation; photoinhition
Date issued
2018-01Department
Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and MemoryJournal
Cell Reports
Publisher
Elsevier
Citation
Beyeler, Anna et al. “Organization of Valence-Encoding and Projection-Defined Neurons in the Basolateral Amygdala.” Cell Reports 22, 4 (January 2018): 905–918 © 2018 The Authors
Version: Final published version
ISSN
2211-1247