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dc.contributor.authorWong, Gee
dc.contributor.authorMarkham, Peter M.
dc.contributor.authorKunio, Mie
dc.contributor.authorEdelman, Elazer R
dc.date.accessioned2018-04-24T18:22:41Z
dc.date.available2018-04-24T18:22:41Z
dc.date.issued2018-01
dc.date.submitted2017-07
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1721.1/114942
dc.description.abstractThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Sex-related differences have been noted in cardiovascular anatomy, pathophysiology, and treatment responses, yet we continued to drive evaluation of vascular device development in animal models without consideration of animal sex. We aimed to understand sex-related differences in the vascular responses to stent implantation by analyzing the pooled data of endovascular interventions in 164 Yucatan mini-swine (87 female, 77 male). Bare metal stents (BMS) or drug-eluting stents (DES) were implanted in 212 coronary arteries (63 single BMS implantation, 68 single DES implantation, 33 overlapped BMS implantation, and 48 overlapped DES implantation). Histomorphological parameters were evaluated from vascular specimens at 3–365 days after stent implantation and evaluated values were compared between female and male groups. While neointima formation at all times after implantation was invariant to sex, statistically significant differences between female and male groups were observed in injury, inflammation, adventitial fibrosis, and neointimal fibrin deposition. These differences were observed independently, i.e., for different procedure types and at different follow-up timings. Only subtle temporal sex-related differences were observed in extent and timing of resolution of inflammation and fibrin clearance. These subtle sex-related differences may be increasingly important as interventional devices meld novel materials that Erode and innovations in drug delivery. Erodible materials may act differently if inflammation has a different temporal sequence with sex, and drug distribution after balloon or stent delivery might be different if the fibrin clearance speaks to different modes of pharmacokinetics in male and female swine.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01 GM49039)en_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1371/journal.pone.0192004en_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourcePLoSen_US
dc.titleSex differences in the outcomes of stent implantation in mini-swine modelen_US
dc.typeArticleen_US
dc.identifier.citationKunio, Mie et al. “Sex Differences in the Outcomes of Stent Implantation in Mini-Swine Model.” Edited by Mohammad R. K. Mofrad. PLOS ONE 13, 1 (January 2018): e0192004 © 2018 Kunio et alen_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.mitauthorKunio, Mie
dc.contributor.mitauthorEdelman, Elazer R
dc.relation.journalPLOS ONEen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-04-20T18:18:31Z
dspace.orderedauthorsKunio, Mie; Wong, Gee; Markham, Peter M.; Edelman, Elazer R.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-0525-4723
dc.identifier.orcidhttps://orcid.org/0000-0002-7832-7156
mit.licensePUBLISHER_CCen_US


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