Show simple item record

dc.contributor.authorPablo-Trinidad, Alberto
dc.contributor.authorCerrato, Carolina
dc.contributor.authorHumala, Karem
dc.contributor.authorFabra Urdiola, Marta
dc.contributor.authorDel Rio, Candice
dc.contributor.authorValles, Betsy
dc.contributor.authorVakoc, Benjamin J.
dc.contributor.authorPadera, Timothy P.
dc.contributor.authorLedesma-Carbayo, María J.
dc.contributor.authorChen, Yi-Bin
dc.contributor.authorHochberg, Ephraim P.
dc.contributor.authorBourquard, Aurelien
dc.contributor.authorButterworth, Ian Richard
dc.contributor.authorSanchez Ferro, Alvaro
dc.contributor.authorTucker-Schwartz, Jason Michael
dc.contributor.authorLee, Elizabeth S.
dc.contributor.authorGray, Martha L
dc.contributor.authorCastro Gonzalez, Carlos
dc.date.accessioned2018-05-09T17:38:12Z
dc.date.available2018-05-09T17:38:12Z
dc.date.issued2018-03
dc.date.submitted2017-11
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/1721.1/115261
dc.description.abstractWhite-blood-cell (WBC) assessment is employed for innumerable clinical procedures as one indicator of immune status. Currently, WBC determinations are obtained by clinical laboratory analysis of whole blood samples. Both the extraction of blood and its analysis limit the accessibility and frequency of the measurement. In this study, we demonstrate the feasibility of a non-invasive device to perform point-of-care WBC analysis without the need for blood draws, focusing on a chemotherapy setting where patients' neutrophils - the most common type of WBC - become very low. In particular, we built a portable optical prototype, and used it to collect 22 microcirculatory-video datasets from 11 chemotherapy patients. Based on these videos, we identified moving optical absorption gaps in the flow of red cells, using them as proxies to WBC movement through nailfold capillaries. We then showed that counting these gaps allows discriminating cases of severe neutropenia ( < 500 neutrophils per μL), associated with increased risks of life-threatening infections, from non-neutropenic cases ( > 1,500 neutrophils per μL). This result suggests that the integration of optical imaging, consumer electronics, and data analysis can make non-invasive screening for severe neutropenia accessible to patients. More generally, this work provides a first step towards a long-term objective of non-invasive WBC counting.en_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/s41598-018-23591-0en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceScientific Reportsen_US
dc.titleNon-invasive detection of severe neutropenia in chemotherapy patients by optical imaging of nailfold microcirculationen_US
dc.typeArticleen_US
dc.identifier.citationBourquard, Aurélien et al. “Non-Invasive Detection of Severe Neutropenia in Chemotherapy Patients by Optical Imaging of Nailfold Microcirculation.” Scientific Reports 8, 1 (March 2018): 5301 © 2018 The Author(s)en_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.mitauthorBourquard, Aurelien
dc.contributor.mitauthorButterworth, Ian Richard
dc.contributor.mitauthorSanchez Ferro, Alvaro
dc.contributor.mitauthorTucker-Schwartz, Jason Michael
dc.contributor.mitauthorLee, Elizabeth S.
dc.contributor.mitauthorGray, Martha L
dc.contributor.mitauthorCastro Gonzalez, Carlos
dc.relation.journalScientific Reportsen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-04-27T17:33:52Z
dspace.orderedauthorsBourquard, Aurélien; Pablo-Trinidad, Alberto; Butterworth, Ian; Sánchez-Ferro, Álvaro; Cerrato, Carolina; Humala, Karem; Fabra Urdiola, Marta; Del Rio, Candice; Valles, Betsy; Tucker-Schwartz, Jason M.; Lee, Elizabeth S.; Vakoc, Benjamin J.; Padera, Timothy P.; Ledesma-Carbayo, María J.; Chen, Yi-Bin; Hochberg, Ephraim P.; Gray, Martha L.; Castro-González, Carlosen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1380-1125
dc.identifier.orcidhttps://orcid.org/0000-0002-8568-7432
dc.identifier.orcidhttps://orcid.org/0000-0003-2951-6943
mit.licensePUBLISHER_CCen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record