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dc.contributor.authorMaher, Erin E.
dc.contributor.authorWelsh, Christina A.
dc.contributor.authorStevens, Beth
dc.contributor.authorErisir, Alev
dc.contributor.authorSchecter, Rachel Ward
dc.contributor.authorBear, Mark
dc.date.accessioned2018-05-10T14:37:06Z
dc.date.available2018-05-10T14:37:06Z
dc.date.issued2017-11
dc.date.submitted2017-09
dc.identifier.issn0270-6474
dc.identifier.issn1529-2401
dc.identifier.urihttp://hdl.handle.net/1721.1/115288
dc.description.abstractBrief monocular deprivation (MD) shifts ocular dominance and reduces the density of thalamic synapses in layer 4 of the mouse primary visual cortex (V1). We found that microglial lysosome content is also increased as a result of MD. Previous studies have shown that the microglial fractalkine receptor CX3CR1 is involved in synaptic development and hippocampal plasticity.Wetherefore tested the hypothesis that neuron-to-microglial communication via CX3CR1 is an essential component of visual cortical development and plasticity in male mice. Our data show that CX3CR1 is not required for normal development of V1 responses to visual stimulation, multiple forms of experience-dependent plasticity, or the synapse loss that accompanies MD in layer 4. By ruling out an essential role for fractalkine signaling, our study narrows the search for understanding how microglia respond to active synapse modification in the visual cortex. Keywords: microglia; ocular dominance plasticity; stimulus-selective response potentiation; synaptic plasticity; visual cortexen_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-EY012309)en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant R01-EY0237)en_US
dc.publisherSociety for Neuroscienceen_US
dc.relation.isversionofhttp://dx.doi.org/10.1523/JNEUROSCI.2679-16.2017en_US
dc.rightsAttribution 4.0 International (CC BY 4.0)en_US
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.sourceSociety for Neuroscienceen_US
dc.titleExperience-dependent synaptic plasticity in V1 occurs without microglial CX3CR1en_US
dc.typeArticleen_US
dc.identifier.citationSchecter, Rachel W. et al. “Experience-Dependent Synaptic Plasticity in V1 Occurs Without Microglial CX3CR1.” The Journal of Neuroscience (September 2017): 2679–16 © 2017 The Authorsen_US
dc.contributor.departmentPicower Institute for Learning and Memoryen_US
dc.contributor.mitauthorSchecter, Rachel Ward
dc.contributor.mitauthorBear, Mark
dc.relation.journalJournal of Neuroscienceen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-05-04T15:37:57Z
dspace.orderedauthorsSchecter, Rachel W.; Maher, Erin E.; Welsh, Christina A.; Stevens, Beth; Erisir, Alev; Bear, Mark F.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1986-4207
mit.licensePUBLISHER_CCen_US


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