dc.contributor.author | Klotz, Alexander | |
dc.contributor.author | Soh, Beatrice W | |
dc.contributor.author | Doyle, Patrick S | |
dc.date.accessioned | 2018-05-10T18:12:09Z | |
dc.date.available | 2018-05-10T18:12:09Z | |
dc.date.issued | 2018-05 | |
dc.date.submitted | 2018-02 | |
dc.identifier.issn | 0031-9007 | |
dc.identifier.issn | 1079-7114 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/115296 | |
dc.description.abstract | Knots in DNA occur in biological systems, serve as a model system for polymer entanglement, and affect the efficacy of modern genomics technologies. We study the motion of complex knots in DNA by stretching molecules with a divergent electric field that provides an elongational force. We demonstrate that the motion of knots is nonisotropic and driven towards the closest end of the molecule. We show for the first time experimentally that knots can go from a mobile to a jammed state by varying an applied strain rate, and that this jamming is reversible. We measure the mobility of knots as a function of strain rate, demonstrating the conditions under which knots can be driven towards the ends of the molecule and untied. | en_US |
dc.publisher | American Physical Society | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1103/PhysRevLett.120.188003 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | American Physical Society | en_US |
dc.title | Motion of Knots in DNA Stretched by Elongational Fields | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Klotz, Alexander R. et al. "Motion of Knots in DNA Stretched by Elongational Fields." Physical Review Letters 120, 18 (May 2018): 188003 © 2018 American Physical Society | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.mitauthor | Klotz, Alexander | |
dc.contributor.mitauthor | Soh, Beatrice W | |
dc.contributor.mitauthor | Doyle, Patrick S | |
dc.relation.journal | Physical Review Letters | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2018-05-03T18:00:15Z | |
dc.language.rfc3066 | en | |
dc.rights.holder | American Physical Society | |
dspace.orderedauthors | Klotz, Alexander R.; Soh, Beatrice W.; Doyle, Patrick S. | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-8399-5995 | |
dc.identifier.orcid | https://orcid.org/0000-0003-2147-9172 | |
mit.license | PUBLISHER_POLICY | en_US |