HapTree-X: An Integrative Bayesian Framework for Haplotype Reconstruction from Transcriptome and Genome Sequencing Data

Author(s)
Berger, Emily R; Yorukoglu, Deniz; Berger Leighton, Bonnie
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Abstract
By running standard genotype calling tools, it is possible to accurately identify the number of wild type and mutant alleles for each single-nucleotide polymorphism (SNP) site. However, in the case of two heterozygous SNP sites, genotype calling tools cannot determine whether mutant alleles from different SNP loci are on the same chromosome or on different homologous chromosomes (i.e. compound heterozygote).
Date issued
2015-03
URI
http://hdl.handle.net/1721.1/115432
Department
Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory; Massachusetts Institute of Technology. Department of Mathematics
Journal
Research in Computational Molecular Biology
Publisher
Springer Nature
Citation
Berger, Emily et al. “HapTree-X: An Integrative Bayesian Framework for Haplotype Reconstruction from Transcriptome and Genome Sequencing Data.” Research in Computational Molecular Biology (2015): 28–29 © 2015 Springer International Publishing Switzerland
Version: Author's final manuscript
ISBN
978-3-319-16705-3
978-3-319-16706-0
ISSN
0302-9743
1611-3349
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