The aneuploidy paradox: costs and benefits of an incorrect karyotype
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nihms315289.pdf
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Author(s)
Sheltzer, Jason Meyer
Amon, Angelika B.
Date Issued
August 2011
Journal
Trends in Genetics
Publisher
Elsevier
Citation
Sheltzer, Jason M. and Angelika Amon. “The Aneuploidy Paradox: Costs and Benefits of an Incorrect Karyotype.” Trends in Genetics 27, 11 (November 2011): 446–453 © 2011 Elsevier Ltd
Version
Author's final manuscript
Abstract
Aneuploidy has a paradoxical effect on cell proliferation. In all normal cells analyzed to date, aneuploidy has been found to decrease the rate of cell proliferation. Yet, aneuploidy is also a hallmark of cancer, a disease of enhanced proliferative capacity, and aneuploid cells are frequently recovered following the experimental evolution of microorganisms. Thus, in certain contexts, aneuploidy might also have growth-advantageous properties. New models of aneuploidy and chromosomal instability have shed light on the diverse effects that karyotypic imbalances have on cellular phenotypes, and suggest novel ways of understanding the role of aneuploidy in development and disease.
MIT Department
Massachusetts Institute of Technology. Department of Biology
Koch Institute for Integrative Cancer Research at MIT
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Creative Commons Attribution-NonCommercial-NoDerivs License
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DOI of Published Version
https://doi.org/10.1016/j.tig.2011.07.003
