Gamete Formation Resets the Aging Clock in Yeast
Author(s)Unal, Elcin; Amon, Angelika B
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Gametogenesis is a process whereby a germ cell differentiates into haploid gametes. We found that, in budding yeast, replicatively aged cells remove age-induced cellular damage during gametogenesis. Importantly, gametes of aged cells have the same replicative potential as those derived from young cells, indicating that life span resets during gametogenesis. Here, we explore the potential mechanisms responsible for gametogenesis-induced rejuvenation and discuss putative analogous mechanisms in higher eukaryotes.
DepartmentMassachusetts Institute of Technology. Department of Biology; Koch Institute for Integrative Cancer Research at MIT
Cold Spring Harbor Symposia on Quantitative Biology
Cold Spring Harbor Laboratory
Unal, E., and A. Amon. “Gamete Formation Resets the Aging Clock in Yeast.” Cold Spring Harbor Symposia on Quantitative Biology 76, no. 0 (January 1, 2011): 73–80.
Author's final manuscript