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dc.contributor.authorLee, Joo-Hyeon
dc.contributor.authorHofree, Matan
dc.contributor.authorChoi, Jinwook
dc.contributor.authorHan, Seungmin
dc.contributor.authorPaschini, Margherita
dc.contributor.authorBhang, Dong Ha
dc.contributor.authorKim, Carla F.
dc.contributor.authorTammela, Tuomas
dc.contributor.authorMarjanovic, Nemanja
dc.contributor.authorCanner, David Allen
dc.contributor.authorWu, Katherine
dc.contributor.authorJacks, Tyler E.
dc.contributor.authorRegev, Aviv
dc.date.accessioned2018-06-25T14:58:01Z
dc.date.available2018-06-25T14:58:01Z
dc.date.issued2017-09
dc.date.submitted2017-06
dc.identifier.issn0092-8674
dc.identifier.issn1097-4172
dc.identifier.urihttp://hdl.handle.net/1721.1/116555
dc.description.abstractThe diversity of mesenchymal cell types in the lung that influence epithelial homeostasis and regeneration is poorly defined. We used genetic lineage tracing, single-cell RNA sequencing, and organoid culture approaches to show that Lgr5 and Lgr6, well-known markers of stem cells in epithelial tissues, are markers of mesenchymal cells in the adult lung. Lgr6 + cells comprise a subpopulation of smooth muscle cells surrounding airway epithelia and promote airway differentiation of epithelial progenitors via Wnt-Fgf10 cooperation. Genetic ablation of Lgr6 + cells impairs airway injury repair in vivo. Distinct Lgr5 + cells are located in alveolar compartments and are sufficient to promote alveolar differentiation of epithelial progenitors through Wnt activation. Modulating Wnt activity altered differentiation outcomes specified by mesenchymal cells. This identification of region- and lineage-specific crosstalk between epithelium and their neighboring mesenchymal partners provides new understanding of how different cell types are maintained in the adult lung. Keywords: mesenchymal cells; bronchiolar epithelium; alveolar epithelium; lung stem cells; lung; differentiation; niche; Wnt signalingen_US
dc.publisherElsevier BVen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/J.CELL.2017.07.028en_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceElsevieren_US
dc.titleAnatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6en_US
dc.typeArticleen_US
dc.identifier.citationLee, Joo-Hyeon et al. “Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6.” Cell 170, 6 (September 2017): 1149–1163 © 2017 The Authorsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorTammela, Tuomas
dc.contributor.mitauthorMarjanovic, Nemanja
dc.contributor.mitauthorCanner, David Allen
dc.contributor.mitauthorWu, Katherine
dc.contributor.mitauthorJacks, Tyler E.
dc.contributor.mitauthorRegev, Aviv
dc.relation.journalCellen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-06-25T14:13:25Z
dspace.orderedauthorsLee, Joo-Hyeon; Tammela, Tuomas; Hofree, Matan; Choi, Jinwook; Marjanovic, Nemanja Despot; Han, Seungmin; Canner, David; Wu, Katherine; Paschini, Margherita; Bhang, Dong Ha; Jacks, Tyler; Regev, Aviv; Kim, Carla F.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-3675-6961
dc.identifier.orcidhttps://orcid.org/0000-0002-0060-7131
dc.identifier.orcidhttps://orcid.org/0000-0001-5785-8911
dc.identifier.orcidhttps://orcid.org/0000-0001-8567-2049
dspace.mitauthor.errortrue
mit.licensePUBLISHER_CCen_US


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