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Designing helical peptide inhibitors of protein–protein interactions

Author(s)
Rezaei Araghi, Raheleh; Keating, Amy E.
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Abstract
Short helical peptides combine characteristics of small molecules and large proteins and provide an exciting area of opportunity in protein design. A growing number of studies report novel helical peptide inhibitors of protein-protein interactions. New techniques have been developed for peptide design and for chemically stabilizing peptides in a helical conformation, which frequently improves protease resistance and cell permeability. We summarize advances in peptide crosslinking chemistry and give examples of peptide design studies targeting coiled-coil transcription factors, Bcl-2 family proteins, MDM2/MDMX, and HIV gp41, among other targets.
Date issued
2016-04
URI
http://hdl.handle.net/1721.1/116643
Department
Massachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biology
Journal
Current Opinion in Structural Biology
Publisher
Elsevier
Citation
Rezaei Araghi, Raheleh, and Amy E Keating. “Designing Helical Peptide Inhibitors of Protein–protein Interactions.” Current Opinion in Structural Biology 39 (August 2016): 27–38 © 2016 Published by Elsevier Ltd
Version: Author's final manuscript
ISSN
0959-440X

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