Designing helical peptide inhibitors of protein–protein interactions
Author(s)Rezaei Araghi, Raheleh; Keating, Amy E.
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Short helical peptides combine characteristics of small molecules and large proteins and provide an exciting area of opportunity in protein design. A growing number of studies report novel helical peptide inhibitors of protein-protein interactions. New techniques have been developed for peptide design and for chemically stabilizing peptides in a helical conformation, which frequently improves protease resistance and cell permeability. We summarize advances in peptide crosslinking chemistry and give examples of peptide design studies targeting coiled-coil transcription factors, Bcl-2 family proteins, MDM2/MDMX, and HIV gp41, among other targets.
DepartmentMassachusetts Institute of Technology. Department of Biological Engineering; Massachusetts Institute of Technology. Department of Biology
Current Opinion in Structural Biology
Rezaei Araghi, Raheleh, and Amy E Keating. “Designing Helical Peptide Inhibitors of Protein–protein Interactions.” Current Opinion in Structural Biology 39 (August 2016): 27–38 © 2016 Published by Elsevier Ltd
Author's final manuscript