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dc.contributor.authorSun, Lei
dc.contributor.authorKnoll, Marko
dc.contributor.authorLodish, Harvey F
dc.date.accessioned2018-06-29T19:16:01Z
dc.date.available2018-06-29T19:16:01Z
dc.date.issued2015-01
dc.identifier.issn1759-5029
dc.identifier.issn1759-5037
dc.identifier.urihttp://hdl.handle.net/1721.1/116703
dc.description.abstractLong non-coding RNAs (lncRNAs) are a large and diverse group of RNAs that are often lineage-specific and that regulate multiple biological functions. Many are nuclear and are essential parts of ribonucleoprotein complexes that modify chromatin segments and establish active or repressive chromatin states; others are cytosolic and regulate the stability of mRNA or act as microRNA sponges. This Review summarizes the current knowledge of lncRNAs as regulators of the endocrine system, with a focus on the identification and mode of action of several endocrine-important lncRNAs. We highlight lncRNAs that have a role in the development and function of pancreatic β cells, white and brown adipose tissue, and other endocrine organs, and discuss the involvement of these molecules in endocrine dysfunction (for example, diabetes mellitus). We also address the associations of lncRNAs with nuclear receptors involved in major hormonal signalling pathways, such as estrogen and androgen receptors, and the relevance of these associations in certain endocrine cancers.en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant NRF-2011NRF-NRFF 001-025)en_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/NRENDO.2014.229en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleLong non-coding RNAs as regulators of the endocrine systemen_US
dc.typeArticleen_US
dc.identifier.citationKnoll, Marko et al. “Long Non-Coding RNAs as Regulators of the Endocrine System.” Nature Reviews Endocrinology 11, 3 (January 2015): 151–160 © 2015 Macmillan Publishers Limiteden_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.mitauthorKnoll, Marko
dc.contributor.mitauthorLodish, Harvey F
dc.relation.journalNature Reviews Endocrinologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-06-29T15:40:08Z
dspace.orderedauthorsKnoll, Marko; Lodish, Harvey F.; Sun, Leien_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-7029-7415
mit.licenseOPEN_ACCESS_POLICYen_US


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