| dc.contributor.author | Chan, Michelle M | |
| dc.contributor.author | Smith, Zachary D | |
| dc.contributor.author | Egli, Dieter | |
| dc.contributor.author | Regev, Aviv | |
| dc.contributor.author | Meissner, Alexander | |
| dc.contributor.author | Chan, Michelle Mei Wah | |
| dc.date.accessioned | 2018-07-03T15:34:47Z | |
| dc.date.available | 2018-07-03T15:34:47Z | |
| dc.date.issued | 2012-08 | |
| dc.date.submitted | 2012-01 | |
| dc.identifier.issn | 1061-4036 | |
| dc.identifier.issn | 1546-1718 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/116756 | |
| dc.description.abstract | Enucleated oocytes have the distinctive ability to reprogram somatic nuclei back to totipotency. Here, we investigate genome-scale DNA methylation patterns after nuclear transfer and compare them to the dynamics at fertilization. We identify specific targets for DNA demethylation after nuclear transfer, such as germline-associated promoters, as well as unique limitations that include certain repetitive element classes. | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Grant 5DP1OD003958) | en_US |
| dc.publisher | Nature Publishing Group | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1038/ng.2382 | en_US |
| dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
| dc.source | PMC | en_US |
| dc.title | Mouse ooplasm confers context-specific reprogramming capacity | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Chan, Michelle M et al. “Mouse Ooplasm Confers Context-Specific Reprogramming Capacity.” Nature Genetics 44, 9 (August 2012): 978–980 © 2012 Nature America, Inc | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Computational and Systems Biology Program | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biology | en_US |
| dc.contributor.mitauthor | Chan, Michelle Mei Wah | |
| dc.contributor.mitauthor | Regev, Aviv | |
| dc.relation.journal | Nature Genetics | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2018-07-03T14:33:15Z | |
| dspace.orderedauthors | Chan, Michelle M; Smith, Zachary D; Egli, Dieter; Regev, Aviv; Meissner, Alexander | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0001-8567-2049 | |
| mit.license | PUBLISHER_POLICY | en_US |
