Antagonistic negative and positive neurons of the basolateral amygdala
Author(s)Itohara, Shigeyoshi; Kim, Joshua; Pignatelli di Spinazzola, Michele; Xu, Sangyu; Tonegawa, Susumu
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The basolateral amygdala (BLA) is a site of convergence of negative and positive stimuli and is critical for emotional behaviors and associations. However, the neural substrate for negative and positive behaviors and relationship between negative and positive representations in the basolateral amygdala are unknown. Here we identify two genetically distinct, spatially segregated populations of excitatory neurons in the mouse BLA that participate in valence-specific behaviors and are connected through mutual inhibition. These results identify a genetically defined neural circuit for the antagonistic control of emotional behaviors and memories.
DepartmentMassachusetts Institute of Technology. Department of Biology; Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences; Picower Institute for Learning and Memory
Nature Publishing Group
Kim, Joshua et al. “Antagonistic Negative and Positive Neurons of the Basolateral Amygdala.” Nature Neuroscience 19, 12 (October 2016): 1636–1646 © 2016 Nature America, Inc., part of Springer Nature
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