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dc.contributor.authorOuyang, Wei
dc.contributor.authorYe, Xinghui
dc.contributor.authorLi, Zirui
dc.contributor.authorHan, Jongyoon
dc.date.accessioned2018-07-12T13:52:37Z
dc.date.available2018-07-12T13:52:37Z
dc.date.issued2018-05
dc.date.submitted2018-03
dc.identifier.issn2040-3364
dc.identifier.issn2040-3372
dc.identifier.urihttp://hdl.handle.net/1721.1/116924
dc.description.abstractThe electrokinetic molecular concentration (EMC) effect at the micro-nanofluidic interface, which enables million-fold preconcentration of biomolecules, is one of the most compelling yet least understood nanofluidic phenomena. Despite the tremendous interests in EMC and the substantial efforts devoted, the detailed mechanism of EMC remains an enigma so far owing to its high complexity, which gives rise to the significant scientific controversies outstanding for over a decade and leaves the precise engineering of EMC devices infeasible. We report a series of experimental and theoretical new findings that decipher the mechanism of EMC. We demonstrate the first elucidation of two separate operating regimes of EMC, and establish the first theoretical model that analytically yet concisely describes the system. We further unveil the dramatically different scaling behaviors of EMC in the two regimes, thereby clarifying the long-lasting controversies. We believe this work represents important progress towards the scientific understanding of EMC and related nano-electrokinetic systems, and would enable the rational design and optimization of EMC devices for a variety of applications.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant No. U19AI109755)en_US
dc.description.sponsorshipNational Science Council (China) (Grant No. 11372229)en_US
dc.description.sponsorshipNational Science Council (China) (Grant No. 21576130)en_US
dc.description.sponsorshipNational Science Council (China) (Grant No. 21490584)en_US
dc.publisherRoyal Society of Chemistry (RSC)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1039/c8nr02170hen_US
dc.rightsCreative Commons Attribution-NonCommercial 3.0 Unporteden_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/3.0/en_US
dc.sourceRoyal Society of Chemistryen_US
dc.titleDeciphering ion concentration polarization-based electrokinetic molecular concentration at the micro-nanofluidic interface: theoretical limits and scaling lawsen_US
dc.typeArticleen_US
dc.identifier.citationOuyang, Wei, Xinghui Ye, Zirui Li, and Jongyoon Han. “Deciphering Ion Concentration Polarization-Based Electrokinetic Molecular Concentration at the Micro-Nanofluidic Interface: Theoretical Limits and Scaling Laws.” Nanoscale (2018).en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Research Laboratory of Electronicsen_US
dc.contributor.mitauthorOuyang, Wei
dc.contributor.mitauthorLi, Zirui
dc.contributor.mitauthorHan, Jongyoon
dc.relation.journalNanoscaleen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-07-11T15:49:54Z
dspace.orderedauthorsOuyang, Wei; Ye, Xinghui; Li, Zirui; Han, Jongyoonen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-4279-661X
dc.identifier.orcidhttps://orcid.org/0000-0001-7215-1439
mit.licensePUBLISHER_CCen_US


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