Understanding the Intersections between Metabolism and Cancer Biology
Author(s)Vander Heiden, Matthew G.; DeBerardinis, Ralph J.
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Transformed cells adapt metabolism to support tumor initiation and progression. Specific metabolic activities can participate directly in the process of transformation or support the biological processes that enable tumor growth. Exploiting cancer metabolism for clinical benefit requires defining the pathways that are limiting for cancer progression and understanding the context specificity of metabolic preferences and liabilities in malignant cells. Progress toward answering these questions is providing new insight into cancer biology and can guide the more effective targeting of metabolism to help patients.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology
Vander Heiden, Matthew G., and Ralph J. DeBerardinis. “Understanding the Intersections Between Metabolism and Cancer Biology.” Cell 168, no. 4 (February 2017): 657–669.
Author's final manuscript