Emerging Biological Principles of Metastasis
Author(s)Lambert, Arthur W.; Pattabiraman, Diwakar R.; Weinberg, Robert A
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Metastases account for the great majority of cancer-associated deaths, yet this complex process remains the least understood aspect of cancer biology. As the body of research concerning metastasis continues to grow at a rapid rate, the biological programs that underlie the dissemination and metastatic outgrowth of cancer cells are beginning to come into view. In this review we summarize the cellular and molecular mechanisms involved in metastasis, with a focus on carcinomas where the most is known, and we highlight the general principles of metastasis that have begun to emerge.
DepartmentLudwig Center for Molecular Oncology; Massachusetts Institute of Technology. Department of Biology
Lambert, Arthur W. et al. “Emerging Biological Principles of Metastasis.” Cell 168, 4 (February 2017): 670–691 © 2017 Elsevier Inc
Author's final manuscript