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dc.contributor.authorCannell, Ian G.
dc.contributor.authorYaffe, Michael B
dc.date.accessioned2018-07-20T17:35:12Z
dc.date.available2018-07-20T17:35:12Z
dc.date.issued2011-07
dc.identifier.issn0090-3493
dc.identifier.urihttp://hdl.handle.net/1721.1/117031
dc.description.abstractDepression of myocardial function during severe sepsis, which currently accounts for approx. 200,000 deaths/year in the United States (1), is characterized by a decrease in contractility and a poor response to fluid therapy (2). Since the md-1980s it has been recognized that the decreased cardiac function, which undoubtedly contributes to the overall pathophysiology of the septic state, does not arise from factors that are intrinsic to the myocardium, but instead results from the presence of circulating myocardial depressant factors (3, 4). Since much of the massive inflammation and multi-organ dysfunction in sepsis result from the secretion of various cytokines, it was long suspected that these proteins were also responsible, at least in part, for the observed myocardial dysfunction, although their identification, and the molecular basis for their effects on myocyte function were poorly understood.en_US
dc.publisherWolters Kluwer - Lippincott Williams & Wilkinsen_US
dc.relation.isversionofhttp://dx.doi.org/10.1097/CCM.0b013e3182204ad1en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourcePMCen_US
dc.titleSalvaging the septic heart through targeting the IL-6/p38 MAPK signaling networken_US
dc.typeArticleen_US
dc.identifier.citationCannell, Ian G., and Michael B. Yaffe. “Salvaging the Septic Heart through Targeting the Interleukin-6/p38 Mitogen-Activated Protein Kinase Signaling Network*.” Critical Care Medicine 39, no. 7 (July 2011): 1836–1837.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.mitauthorYaffe, Michael B
dc.relation.journalCritical Care Medicineen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-07-13T15:17:05Z
dspace.orderedauthorsCannell, Ian G.; Yaffe, Michael B.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-9547-3251
mit.licenseOPEN_ACCESS_POLICYen_US


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