A team effort: natural killer cells on the first leg of the tumor immunity relay race
Author(s)Fessenden, Timothy B; Duong, Ellen; Spranger-Zimmermann, Stefani
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Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tumor immunity. This work highlights the cooperative nature of anti-tumor immunity set in motion by Natural Killer cells, and immune evasion by tumors through their exclusion.
DepartmentMassachusetts Institute of Technology. Department of Biology
Journal for ImmunoTherapy of Cancer
Biomed Central Ltd.
Fessenden, Timothy B., et al. “A Team Effort: Natural Killer Cells on the First Leg of the Tumor Immunity Relay Race.” Journal for ImmunoTherapy of Cancer, vol. 6, no. 1, Dec. 2018. © 2018 The Author(s)
Final published version