A team effort: natural killer cells on the first leg of the tumor immunity relay race
Author(s)
Fessenden, Timothy B; Duong, Ellen; Spranger-Zimmermann, Stefani
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Recent work by Böttcher and colleagues defines a new role for Natural Killer cells in the anti-tumor immune response, arriving early into the tumor microenvironment before passing the baton to DC1 dendritic cells. DC1 dendritic cells subsequently activate CD8+ T cells resulting in effective anti-tumor immunity. This work highlights the cooperative nature of anti-tumor immunity set in motion by Natural Killer cells, and immune evasion by tumors through their exclusion.
Date issued
2018-07Department
Massachusetts Institute of Technology. Department of BiologyJournal
Journal for ImmunoTherapy of Cancer
Publisher
Biomed Central Ltd.
Citation
Fessenden, Timothy B., et al. “A Team Effort: Natural Killer Cells on the First Leg of the Tumor Immunity Relay Race.” Journal for ImmunoTherapy of Cancer, vol. 6, no. 1, Dec. 2018. © 2018 The Author(s)
Version: Final published version
ISSN
2051-1426