Show simple item record

dc.contributor.authorVillani, Valentina
dc.contributor.authorBuono, Roberta
dc.contributor.authorWei, Min
dc.contributor.authorKumar, Sanjeev
dc.contributor.authorCohen, Pinchas
dc.contributor.authorSneddon, Julie B.
dc.contributor.authorPerin, Laura
dc.contributor.authorLongo, Valter D.
dc.contributor.authorCheng, Chia-Wei
dc.contributor.authorYilmaz, Omer
dc.date.accessioned2018-07-23T18:50:49Z
dc.date.available2018-07-23T18:50:49Z
dc.date.issued2017-02
dc.date.submitted2016-11
dc.identifier.issn0092-8674
dc.identifier.issn1097-4172
dc.identifier.urihttp://hdl.handle.net/1721.1/117051
dc.description.abstractStem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to organ regeneration pose major challenges. In mice, a 4-day fasting mimicking diet (FMD) induces a stepwise expression of Sox17 and Pdx-1, followed by Ngn3-driven generation of insulin-producing β cells, resembling that observed during pancreatic development. FMD cycles restore insulin secretion and glucose homeostasis in both type 2 and type 1 diabetes mouse models. In human type 1 diabetes pancreatic islets, fasting conditions reduce PKA and mTOR activity and induce Sox2 and Ngn3 expression and insulin production. The effects of the FMD are reversed by IGF-1 treatment and recapitulated by PKA and mTOR inhibition. These results indicate that a FMD promotes the reprogramming of pancreatic cells to restore insulin generation in islets from T1D patients and reverse both T1D and T2D phenotypes in mouse models.en_US
dc.publisherElsevier BVen_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/J.CELL.2017.01.040en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleFasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetesen_US
dc.typeArticleen_US
dc.identifier.citationCheng, Chia-Wei et al. “Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes.” Cell 168, 5 (February 2017): 775–788 © 2017 Elsevier Incen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorCheng, Chia-Wei
dc.contributor.mitauthorYilmaz, Omer
dc.relation.journalCellen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-07-13T16:10:23Z
dspace.orderedauthorsCheng, Chia-Wei; Villani, Valentina; Buono, Roberta; Wei, Min; Kumar, Sanjeev; Yilmaz, Omer H.; Cohen, Pinchas; Sneddon, Julie B.; Perin, Laura; Longo, Valter D.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-1088-923X
dc.identifier.orcidhttps://orcid.org/0000-0002-7577-4612
mit.licensePUBLISHER_CCen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record