dc.contributor.author | Beyaz, Semir | |
dc.contributor.author | Yilmaz, Omer | |
dc.date.accessioned | 2018-07-23T19:07:24Z | |
dc.date.available | 2018-07-23T19:07:24Z | |
dc.date.issued | 2016-10 | |
dc.date.submitted | 2016-09 | |
dc.identifier.issn | 1078-0432 | |
dc.identifier.issn | 1557-3265 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/117054 | |
dc.description.abstract | Peroxisome proliferator-activated receptor delta (PPAR-8) is a nuclear receptor transcription factor that regulates gene expression during development and disease states, such as cancer. However, the precise role of PPAR-8 during tumorigenesis is not well understood. Recent data suggest that PPAR-8 may have context-specific oncogenic and tumor-suppressive roles depending on the tissue, cell-type, or diet-induced physiology in question. For example, in the intestine, pro-obesity diets, such as a high-fat diet (HFD), are associated with increased colorectal cancer incidence. Interestingly, many of the effects of an HFD in the stem and progenitor cell compartment are driven by a robust PPAR-8 program and contribute to the early steps of intestinal tumorigenesis. Importantly, the PPAR-8 pathway or its downstream mediators may serve as therapeutic intervention points or biomarkers in colon cancer that arise in patients who are obese. Although potent PPAR-8 agonists and antagonists exist, their clinical utility may be enhanced by uncovering how PPAR-8 mediates tumorigenesis in diverse tissues and cell types as well as in response to diet. | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant R00-AG045144) | en_US |
dc.publisher | American Association for Cancer Research (AACR) | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1158/1078-0432.CCR-16-0775 | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | PMC | en_US |
dc.title | Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR- Pathway | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Beyaz, S. and O. H. Yilmaz. “Molecular Pathways: Dietary Regulation of Stemness and Tumor Initiation by the PPAR- Pathway.” Clinical Cancer Research 22, 23 (October 2016): 5636–5641 © 2016 American Association for Cancer Research | en_US |
dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
dc.contributor.mitauthor | Beyaz, Semir | |
dc.contributor.mitauthor | Yilmaz, Omer | |
dc.relation.journal | Clinical Cancer Research | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2018-07-13T16:18:07Z | |
dspace.orderedauthors | Beyaz, S.; Yilmaz, O. H. | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-7577-4612 | |
mit.license | OPEN_ACCESS_POLICY | en_US |