Metabolic Teamwork in the Stem Cell Niche
Author(s)Roper, Jatin; Yilmaz, Omer
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Nearby cells can support stem cell differentiation, but the metabolic activities in stem cell niches are unknown. A recent study (Rodríguez-Colman et al., 2017) reveals a metabolic partnership in the intestinal stem cell niche: glycolysis in niche Paneth cells provides lactate to drive mitochondrial oxidative phosphorylation in intestinal stem cells.
DepartmentDavid H. Koch Institute for Integrative Cancer Research at MIT; Massachusetts Institute of Technology. Department of Biology
Roper, Jatin, and Ömer H. Yilmaz. “Metabolic Teamwork in the Stem Cell Niche.” Cell Metabolism 25, no. 5 (May 2017): 993–994.
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