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dc.contributor.authorSantaguida, Stefano
dc.contributor.authorAmon, Angelika B
dc.date.accessioned2018-07-30T18:15:42Z
dc.date.available2018-07-30T18:15:42Z
dc.date.issued2015-07
dc.identifier.issn1471-0072
dc.identifier.issn1471-0080
dc.identifier.urihttp://hdl.handle.net/1721.1/117201
dc.description.abstractDividing cells that experience chromosome mis-segregation generate aneuploid daughter cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes with the proliferation of untransformed cells, it is also, paradoxically, a hallmark of cancer, a disease defined by increased proliferative potential. These contradictory effects are also observed in mouse models of chromosome instability (CIN). CIN can inhibit and promote tumorigenesis. Recent work has provided insights into the cellular consequences of CIN and aneuploidy. Chromosome mis-segregation per se can alter the genome in many more ways than just causing the gain or loss of chromosomes. The short- and long-term effects of aneuploidy are caused by gene-specific effects and a stereotypic aneuploidy stress response. Importantly, these recent findings provide insights into the role of aneuploidy in tumorigenesis.en_US
dc.description.sponsorshipNational Institutes of Health (U.S.) (Grant GM56800)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttps://doi.org/10.1038/nrm4025en_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceProf. Amon via Courtney Crummetten_US
dc.titleShort- and long-term effects of chromosome mis-segregation and aneuploidyen_US
dc.typeArticleen_US
dc.identifier.citationSantaguida, Stefano and Angelika Amon. “Short- and Long-Term Effects of Chromosome Mis-Segregation and Aneuploidy.” Nature Reviews Molecular Cell Biology 16, 8 (August 2015): 473–485en_US
dc.contributor.departmentDavid H. Koch Institute for Integrative Cancer Research at MITen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biologyen_US
dc.contributor.approverAmon Aen_US
dc.contributor.mitauthorSantaguida, Stefano
dc.contributor.mitauthorAmon, Angelika B
dc.relation.journalNature Reviews Molecular Cell Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsSantaguida, Stefano; Amon, Angelikaen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-1501-6190
dc.identifier.orcidhttps://orcid.org/0000-0001-9837-0314
mit.licenseOPEN_ACCESS_POLICYen_US


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