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dc.contributor.authorNguyen, Peter Q.
dc.contributor.authorStark, Jessica C.
dc.contributor.authorDonghia, Nina
dc.contributor.authorFerrante, Tom
dc.contributor.authorHsu, Karen J.
dc.contributor.authorDubner, Rachel S.
dc.contributor.authorPardee, Keith
dc.contributor.authorJewett, Michael C.
dc.contributor.authorHuang, Ally
dc.contributor.authorTakahashi, Melissa Kimie
dc.contributor.authorDy, Aaron James
dc.contributor.authorCollins, James J.
dc.date.accessioned2018-08-27T19:42:51Z
dc.date.available2018-08-27T19:42:51Z
dc.date.issued2018-08
dc.date.submitted2018-03
dc.identifier.issn2375-2548
dc.identifier.urihttp://hdl.handle.net/1721.1/117564
dc.description.abstractHands-on demonstrations greatly enhance the teaching of science, technology, engineering, and mathematics (STEM) concepts and foster engagement and exploration in the sciences. While numerous chemistry and physics classroom demonstrations exist, few biology demonstrations are practical and accessible due to the challenges and concerns of growing living cells in classrooms. We introduce BioBits™ Explorer, a synthetic biology educational kit based on shelf-stable, freeze-dried, cell-free (FD-CF) reactions, which are activated by simply adding water. The FD-CF reactions engage the senses of sight, smell, and touch with outputs that produce fluorescence, fragrances, and hydrogels, respectively. We introduce components that can teach tunable protein expression, enzymatic reactions, biomaterial formation, and biosensors using RNA switches, some of which represent original FD-CF outputs that expand the toolbox of cell-free synthetic biology. The BioBits™ Explorer kit enables hands-on demonstrations of cutting-edge science that are inexpensive and easy to use, circumventing many current barriers for implementing exploratory biology experiments in classrooms.en_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/sciadv.aat5105en_US
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en_US
dc.sourceScience Advancesen_US
dc.titleBioBits™ Explorer: A modular synthetic biology education kiten_US
dc.typeArticleen_US
dc.identifier.citationHuang, Ally et al. “BioBits™ Explorer: A Modular Synthetic Biology Education Kit.” Science Advances 4, 8 (August 2018): eaat5105en_US
dc.contributor.departmentInstitute for Medical Engineering and Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.mitauthorHuang, Ally
dc.contributor.mitauthorTakahashi, Melissa Kimie
dc.contributor.mitauthorDy, Aaron James
dc.contributor.mitauthorCollins, James J.
dc.relation.journalScience Advancesen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-08-27T17:12:50Z
dspace.orderedauthorsHuang, Ally; Nguyen, Peter Q.; Stark, Jessica C.; Takahashi, Melissa K.; Donghia, Nina; Ferrante, Tom; Dy, Aaron J.; Hsu, Karen J.; Dubner, Rachel S.; Pardee, Keith; Jewett, Michael C.; Collins, James J.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-8711-8233
dc.identifier.orcidhttps://orcid.org/0000-0003-0319-5416
dc.identifier.orcidhttps://orcid.org/0000-0002-5560-8246
mit.licensePUBLISHER_CCen_US


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