Antibiotic efficacy — context matters
Author(s)
Yang, Jason Hung-Ying; Bening, Sarah; Collins, James J.
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Antibiotic lethality is a complex physiological process, sensitive to external cues. Recent advances using systems approaches have revealed how events downstream of primary target inhibition actively participate in antibiotic death processes. In particular, altered metabolism, translational stress and DNA damage each contribute to antibiotic-induced cell death. Moreover, environmental factors such as oxygen availability, extracellular metabolites, population heterogeneity and multidrug contexts alter antibiotic efficacy by impacting bacterial metabolism and stress responses. Here we review recent studies on antibiotic efficacy and highlight insights gained on the involvement of cellular respiration, redox stress and altered metabolism in antibiotic lethality. We discuss the complexity found in natural environments and highlight knowledge gaps in antibiotic lethality that may be addressed using systems approaches.
Date issued
2017-10Department
Institute for Medical Engineering and Science; Massachusetts Institute of Technology. Department of Biological EngineeringJournal
Current Opinion in Microbiology
Publisher
Elsevier BV
Citation
Yang, Jason H et al. “Antibiotic Efficacy — Context Matters.” Current Opinion in Microbiology 39 (October 2017): 73–80 © 2017 The Authors
Version: Final published version
ISSN
1369-5274