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dc.contributor.authorKong, David S
dc.contributor.authorThorsen, Todd A.
dc.contributor.authorBabb, Jonathan
dc.contributor.authorWick, Scott T.
dc.contributor.authorGam, Jeremy Jonathan
dc.contributor.authorWeiss, Ron
dc.contributor.authorCarr Sr, Peter A.
dc.date.accessioned2018-09-12T19:28:15Z
dc.date.available2018-09-12T19:28:15Z
dc.date.issued2017-06
dc.date.submitted2016-08
dc.identifier.issn1087-0156
dc.identifier.issn1546-1696
dc.identifier.urihttp://hdl.handle.net/1721.1/117729
dc.description.abstractMicrofluidic devices have the potential to automate and miniaturize biological experiments, but open-source sharing of device designs has lagged behind sharing of other resources such as software. Synthetic biologists have used microfluidics for DNA assembly, cell-free expression, and cell culture, but a combination of expense, device complexity, and reliance on custom set-ups hampers their widespread adoption. We present Metafluidics, an open-source, community-driven repository that hosts digital design files, assembly specifications, and open-source software to enable users to build, configure, and operate a microfluidic device. We use Metafluidics to share designs and fabrication instructions for both a microfluidic ring-mixer device and a 32-channel tabletop microfluidic controller. This device and controller are applied to build genetic circuits using standard DNA assembly methods including ligation, Gateway, Gibson, and Golden Gate. Metafluidics is intended to enable a broad community of engineers, DIY enthusiasts, and other nontraditional participants with limited fabrication skills to contribute to microfluidic research.en_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Award R01CA173712)en_US
dc.description.sponsorshipNational Institute of General Medical Sciences (U.S.) (Award P50GM098792)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant 1124247)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant 1522074)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant 1521925)en_US
dc.description.sponsorshipNational Science Foundation (U.S.) (Grant 1521759)en_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttp://dx.doi.org/10.1038/NBT.3873en_US
dc.rightsCreative Commons Attribution 4.0 International Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceNatureen_US
dc.titleOpen-source, community-driven microfluidics with Metafluidicsen_US
dc.typeArticleen_US
dc.identifier.citationKong, David S et al. “Open-Source, Community-Driven Microfluidics with Metafluidics.” Nature Biotechnology 35, 6 (June 2017): 523–529 © 2017 Nature America, Incen_US
dc.contributor.departmentLincoln Laboratoryen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Electrical Engineering and Computer Scienceen_US
dc.contributor.mitauthorKong, David S
dc.contributor.mitauthorThorsen, Todd A.
dc.contributor.mitauthorBabb, Jonathan
dc.contributor.mitauthorWick, Scott T.
dc.contributor.mitauthorGam, Jeremy Jonathan
dc.contributor.mitauthorWeiss, Ron
dc.contributor.mitauthorCarr Sr, Peter A.
dc.relation.journalNature Biotechnologyen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-09-12T14:33:16Z
dspace.orderedauthorsKong, David S; Thorsen, Todd A; Babb, Jonathan; Wick, Scott T; Gam, Jeremy J; Weiss, Ron; Carr, Peter Aen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-4600-0383
dc.identifier.orcidhttps://orcid.org/0000-0003-0396-2443
mit.licensePUBLISHER_CCen_US


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