dc.contributor.author | Hayward, Alison M | |
dc.contributor.author | Bensel, Taylor A | |
dc.contributor.author | Mazdiyasni, Hormoz | |
dc.contributor.author | Rogner, Jaimie L | |
dc.contributor.author | Kirtane, Ameya | |
dc.contributor.author | Lee, Young-Ah | |
dc.contributor.author | Hua, Tiffany P | |
dc.contributor.author | Bajpayee, Ambika Goel | |
dc.contributor.author | Collins, Joy E | |
dc.contributor.author | McDonnell, Shane | |
dc.contributor.author | Cleveland, Cody | |
dc.contributor.author | Lopes, Aaron C | |
dc.contributor.author | Wahane, Aniket Vijay | |
dc.contributor.author | Langer, Robert S | |
dc.contributor.author | Traverso, Carlo Giovanni | |
dc.date.accessioned | 2018-10-10T17:51:40Z | |
dc.date.available | 2018-10-10T17:51:40Z | |
dc.date.issued | 2018-08 | |
dc.date.submitted | 2018-02 | |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/118419 | |
dc.description.abstract | Gastric resident dosage forms have been used successfully in farm animals for the delivery of a variety of drugs helping address the challenge of extended dosing. Despite these advances, there remains a significant challenge across the range of species with large variation in body size. To address this, we investigate a scalable gastric resident platform capable of prolonged retention. We investigate prototypes in dimensions consistent with administration and retention in the stomachs of two species (rabbit and pig). We investigate sustained gastric retention of our scalable dosage form platform, and in pigs show the capacity to modulate drug release kinetics of a model drug in veterinary practice, meloxicam, with our dosage form. The ability to achieve gastric residence and thereby enable sustained drug levels across different species may have a significant impact in the welfare of animals in both research, agricultural, zoological, and clinical practice settings. | en_US |
dc.description.sponsorship | Bill & Melinda Gates Foundation (Grant No. OPP1096734) | en_US |
dc.description.sponsorship | Bill & Melinda Gates Foundation (Grant No. OPP1148627) | en_US |
dc.description.sponsorship | National Institutes of Health (U.S.) (Grant# EB-000244) | en_US |
dc.description.sponsorship | Max Planck Society (Research Award, Award Ltr Dtd. 2/11/08) | en_US |
dc.description.sponsorship | Alexander von Humboldt Foundation | en_US |
dc.description.sponsorship | Brigham and Women's Hospital. Division of Gastroenterology | en_US |
dc.description.sponsorship | Massachusetts Institute of Technology. Division of Comparative Medicine | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1038/s41598-018-30212-3 | en_US |
dc.rights | Creative Commons Attribution 4.0 International License | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.source | Nature | en_US |
dc.title | Scalable Gastric Resident Systems for Veterinary Application | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Hayward, Alison, Taylor Bensel, Hormoz Mazdiyasni, Jaimie Rogner, Ameya R. Kirtane, Young-Ah Lucy Lee, Tiffany Hua, et al. “Scalable Gastric Resident Systems for Veterinary Application.” Scientific Reports 8, no. 1 (August 7, 2018). | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Mechanical Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Division of Comparative Medicine | en_US |
dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
dc.contributor.mitauthor | Hayward, Alison M | |
dc.contributor.mitauthor | Bensel, Taylor A | |
dc.contributor.mitauthor | Mazdiyasni, Hormoz | |
dc.contributor.mitauthor | Rogner, Jaimie L | |
dc.contributor.mitauthor | Kirtane, Ameya | |
dc.contributor.mitauthor | Lee, Young-Ah | |
dc.contributor.mitauthor | Hua, Tiffany P | |
dc.contributor.mitauthor | Bajpayee, Ambika Goel | |
dc.contributor.mitauthor | Collins, Joy E | |
dc.contributor.mitauthor | McDonnell, Shane | |
dc.contributor.mitauthor | Cleveland, Cody | |
dc.contributor.mitauthor | Lopes, Aaron C | |
dc.contributor.mitauthor | Wahane, Aniket Vijay | |
dc.contributor.mitauthor | Langer, Robert S | |
dc.contributor.mitauthor | Traverso, Carlo Giovanni | |
dc.relation.journal | Scientific Reports | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2018-10-10T16:03:01Z | |
dspace.orderedauthors | Hayward, Alison; Bensel, Taylor; Mazdiyasni, Hormoz; Rogner, Jaimie; Kirtane, Ameya R.; Lee, Young-Ah Lucy; Hua, Tiffany; Bajpayee, Ambika; Collins, Joy; McDonnell, Shane; Cleveland, Cody; Lopes, Aaron; Wahane, Aniket; Langer, Robert; Traverso, Giovanni | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-4750-7207 | |
dc.identifier.orcid | https://orcid.org/0000-0003-4255-0492 | |
dc.identifier.orcid | https://orcid.org/0000-0002-4260-2785 | |
mit.license | PUBLISHER_CC | en_US |