Effect of Terminal Modification on the Molecular Assembly and Mechanical Properties of Protein-Based Block Copolymers
Author(s)Jacobsen, Matthew M.; Huang, Wenwen; Li, David; Simon, Marc; Staii, Cristian; Tokareva, Olena; Ebrahimi, Davoud; Ling, Shengjie; Dinjaski, Nina; Buehler, Markus J; Wong, Joyce Y.; Kaplan, David L.; ... Show more Show less
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Accurate prediction and validation of the assembly of bioinspired peptide sequences into fibers with defined mechanical characteristics would aid significantly in designing and creating materials with desired properties. This process may also be utilized to provide insight into how the molecular architecture of many natural protein fibers is assembled. In this work, computational modeling and experimentation are used in tandem to determine how peptide terminal modification affects a fiber-forming core domain. Modeling shows that increased terminal molecular weight and hydrophilicity improve peptide chain alignment under shearing conditions and promote consolidation of semicrystalline domains. Mechanical analysis shows acute improvements to strength and elasticity, but significantly reduced extensibility and overall toughness. These results highlight an important entropic function that terminal domains of fiber-forming peptides exhibit as chain alignment promoters, which ultimately has notable consequences on the mechanical behavior of the final fiber products.
DepartmentMassachusetts Institute of Technology. Department of Civil and Environmental Engineering; Massachusetts Institute of Technology. Department of Materials Science and Engineering; Massachusetts Institute of Technology. Department of Physics; MIT Kavli Institute for Astrophysics and Space Research
Jacobsen, Matthew M., Olena S. Tokareva, Davoud Ebrahimi, Wenwen Huang, Shengjie Ling, Nina Dinjaski, David Li, et al. “Effect of Terminal Modification on the Molecular Assembly and Mechanical Properties of Protein-Based Block Copolymers.” Macromolecular Bioscience 17, no. 9 (June 30, 2017): 1700095.
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