Multiple Sclerosis, Melatonin, and Neurobehavioral Diseases

Abstract

Numerous neurobehavioral diseases typically exhibit annual rhythms in the frequency with which they cause flare-ups. A prime example is the seasonal affective disorder syndrome (SADS), in which symptoms usually start to appear in November and disappear in the late winter, after which many patients remain asymptomatic until the following fall. Smaller seasonal variations in mood and behavior are also sometimes noted among patients with Depression, per se, but less so among normal control subjects.