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dc.contributor.authorNasamu, Armiyaw S.
dc.contributor.authorGlushakova, Svetlana
dc.contributor.authorRusso, Ilaria
dc.contributor.authorVaupel, Barbara
dc.contributor.authorOksman, Anna
dc.contributor.authorKim, Arthur S.
dc.contributor.authorFremont, Daved H.
dc.contributor.authorTolia, Niraj
dc.contributor.authorBeck, Josh R.
dc.contributor.authorMeyers, Marvin J.
dc.contributor.authorZimmerberg, Joshua
dc.contributor.authorGoldberg, Daniel E.
dc.contributor.authorNiles, Jacquin
dc.date.accessioned2018-11-08T15:35:56Z
dc.date.available2018-11-08T15:35:56Z
dc.date.issued2017-10
dc.date.submitted2017-03
dc.identifier.issn0036-8075
dc.identifier.issn1095-9203
dc.identifier.urihttp://hdl.handle.net/1721.1/118955
dc.description.abstractProteases of the malaria parasite Plasmodium falciparum have long been investigated as drug targets. The P. falciparum genome encodes 10 aspartic proteases called plasmepsins, which are involved in diverse cellular processes. Most have been studied extensively but the functions of plasmepsins IX and X (PMIX and PMX) were unknown. Here we show that PMIX is essential for erythrocyte invasion, acting on rhoptry secretory organelle biogenesis. In contrast, PMX is essential for both egress and invasion, controlling maturation of the subtilisin-like serine protease SUB1 in exoneme secretory vesicles. We have identified compounds with potent antimalarial activity targeting PMX, including a compound known to have oral efficacy in a mouse model of malaria.en_US
dc.publisherAmerican Association for the Advancement of Science (AAAS)en_US
dc.relation.isversionofhttp://dx.doi.org/10.1126/SCIENCE.AAN1478en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourcePMCen_US
dc.titlePlasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasionen_US
dc.typeArticleen_US
dc.identifier.citationNasamu, Armiyaw S. et al. “Plasmepsins IX and X Are Essential and Druggable Mediators of Malaria Parasite Egress and Invasion.” Science 358, 6362 (October 2017): 518–522 © 2017 The Authorsen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.mitauthorNiles, Jacquin
dc.relation.journalScienceen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-11-06T14:20:50Z
dspace.orderedauthorsNasamu, Armiyaw S.; Glushakova, Svetlana; Russo, Ilaria; Vaupel, Barbara; Oksman, Anna; Kim, Arthur S.; Fremont, Daved H.; Tolia, Niraj; Beck, Josh R.; Meyers, Marvin J.; Niles, Jacquin C.; Zimmerberg, Joshua; Goldberg, Daniel E.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-6250-8796
mit.licensePUBLISHER_POLICYen_US


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