dc.contributor.author | Lee, Jeong Wook | |
dc.contributor.author | Chan, Clement T. Y. | |
dc.contributor.author | Slomovic, Shimyn | |
dc.contributor.author | Collins, James J. | |
dc.date.accessioned | 2018-11-20T15:48:54Z | |
dc.date.available | 2018-11-20T15:48:54Z | |
dc.date.issued | 2018-05 | |
dc.date.submitted | 2017-05 | |
dc.identifier.issn | 1552-4450 | |
dc.identifier.issn | 1552-4469 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/119226 | |
dc.description.abstract | The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation. | en_US |
dc.description.sponsorship | Defense Threat Reduction Agency (DTRA) (Grant HDTRA1-14-1-0006) | en_US |
dc.description.sponsorship | United States. Air Force Office of Scientific Research (Grant FA9550-14-1-0060) | en_US |
dc.language.iso | en_US | |
dc.publisher | Nature Publishing Group | en_US |
dc.relation.isversionof | https://doi.org/10.1038/s41589-018-0056-x | en_US |
dc.rights | Creative Commons Attribution-Noncommercial-Share Alike | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | en_US |
dc.source | Prof. Collins via Howard Silver | en_US |
dc.title | Next-generation biocontainment systems for engineered organisms | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Lee, Jeong Wook et al. “Next-Generation Biocontainment Systems for Engineered Organisms.” Nature Chemical Biology 14, 6 (May 2018): 530–537 © 2018 Nature Publishing Group | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Institute for Medical Engineering & Science | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Synthetic Biology Center | en_US |
dc.contributor.approver | Collins, James J | en_US |
dc.contributor.mitauthor | Collins, James J. | |
dc.relation.journal | Nature Chemical Biology | en_US |
dc.eprint.version | Author's final manuscript | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dspace.orderedauthors | Lee, Jeong Wook; Chan, Clement T. Y.; Slomovic, Shimyn; Collins, James J. | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-5560-8246 | |
mit.license | OPEN_ACCESS_POLICY | en_US |