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dc.contributor.authorLee, Jeong Wook
dc.contributor.authorChan, Clement T. Y.
dc.contributor.authorSlomovic, Shimyn
dc.contributor.authorCollins, James J.
dc.date.accessioned2018-11-20T15:48:54Z
dc.date.available2018-11-20T15:48:54Z
dc.date.issued2018-05
dc.date.submitted2017-05
dc.identifier.issn1552-4450
dc.identifier.issn1552-4469
dc.identifier.urihttp://hdl.handle.net/1721.1/119226
dc.description.abstractThe increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems. In this perspective, we highlight recent advances in biocontainment and suggest a number of approaches for future development, which may be applied to overcome remaining challenges in safeguard implementation.en_US
dc.description.sponsorshipDefense Threat Reduction Agency (DTRA) (Grant HDTRA1-14-1-0006)en_US
dc.description.sponsorshipUnited States. Air Force Office of Scientific Research (Grant FA9550-14-1-0060)en_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofhttps://doi.org/10.1038/s41589-018-0056-xen_US
dc.rightsCreative Commons Attribution-Noncommercial-Share Alikeen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_US
dc.sourceProf. Collins via Howard Silveren_US
dc.titleNext-generation biocontainment systems for engineered organismsen_US
dc.typeArticleen_US
dc.identifier.citationLee, Jeong Wook et al. “Next-Generation Biocontainment Systems for Engineered Organisms.” Nature Chemical Biology 14, 6 (May 2018): 530–537 © 2018 Nature Publishing Groupen_US
dc.contributor.departmentMassachusetts Institute of Technology. Institute for Medical Engineering & Scienceen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Biological Engineeringen_US
dc.contributor.departmentMassachusetts Institute of Technology. Synthetic Biology Centeren_US
dc.contributor.approverCollins, James Jen_US
dc.contributor.mitauthorCollins, James J.
dc.relation.journalNature Chemical Biologyen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dspace.orderedauthorsLee, Jeong Wook; Chan, Clement T. Y.; Slomovic, Shimyn; Collins, James J.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-5560-8246
mit.licenseOPEN_ACCESS_POLICYen_US


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