| dc.contributor.author | Toth, Michael J. | |
| dc.contributor.author | Sei, Yoshitaka J. | |
| dc.contributor.author | Mulder, Willem J.M. | |
| dc.contributor.author | Fayad, Zahi A. | |
| dc.contributor.author | Farokhzad, Omid C. | |
| dc.contributor.author | Kim, YongTae | |
| dc.contributor.author | Lee Chung, Bomy | |
| dc.contributor.author | Kamaly, Nazila | |
| dc.contributor.author | Langer, Robert S | |
| dc.contributor.author | Becraft, Jacob Robert | |
| dc.date.accessioned | 2018-12-04T17:37:53Z | |
| dc.date.available | 2018-12-04T17:37:53Z | |
| dc.date.issued | 2016-01 | |
| dc.date.submitted | 2015-10 | |
| dc.identifier.issn | 1748-0132 | |
| dc.identifier.uri | http://hdl.handle.net/1721.1/119413 | |
| dc.description.abstract | The endothelium lines the internal surfaces of blood and lymphatic vessels and has a critical role in maintaining homeostasis. Endothelial dysfunction is involved in the pathology of many diseases and conditions, including disorders such as diabetes, cardiovascular diseases, and cancer. Given this common etiology in a range of diseases, medicines targeting an impaired endothelium can strengthen the arsenal of therapeutics. Nanomedicine - the application of nanotechnology to healthcare - presents novel opportunities and potential for the treatment of diseases associated with an impaired endothelium. This review discusses therapies currently available for the treatment of these disorders and highlights the application of nanomedicine for the therapy of these major disease complications. Keywords: Endothelium; Nanomedicine; Endothelial disorder; Diabetes; Atherosclerosis; Cancer | en_US |
| dc.description.sponsorship | National Heart, Lung, and Blood Institute (Contract HHSN268201000045C) | en_US |
| dc.description.sponsorship | National Institutes of Health (U.S.) (Contract HHSN268201000045C) | en_US |
| dc.description.sponsorship | National Cancer Institute (U.S.) (Grant CA151884) | en_US |
| dc.publisher | Elsevier | en_US |
| dc.relation.isversionof | http://dx.doi.org/10.1016/J.NANTOD.2015.11.009 | en_US |
| dc.rights | Creative Commons Attribution-NonCommercial-NoDerivs License | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
| dc.source | PMC | en_US |
| dc.title | Nanomedicines for endothelial disorders | en_US |
| dc.type | Article | en_US |
| dc.identifier.citation | Lee Chung, et al. “Nanomedicines for Endothelial Disorders.” Nano Today 10, 6 (December 2015): 759–776 © 2015 Elsevier Ltd | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Biological Engineering | en_US |
| dc.contributor.department | Massachusetts Institute of Technology. Department of Chemical Engineering | en_US |
| dc.contributor.department | Koch Institute for Integrative Cancer Research at MIT | en_US |
| dc.contributor.mitauthor | Lee Chung, Bomy | |
| dc.contributor.mitauthor | Kamaly, Nazila | |
| dc.contributor.mitauthor | Becraft, Jacob R | |
| dc.contributor.mitauthor | Langer, Robert S | |
| dc.relation.journal | Nano Today | en_US |
| dc.eprint.version | Author's final manuscript | en_US |
| dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
| eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
| dc.date.updated | 2018-12-04T14:20:05Z | |
| dspace.orderedauthors | Lee Chung, Bomy; Toth, Michael J.; Kamaly, Nazila; Sei, Yoshitaka J.; Becraft, Jacob; Mulder, Willem J.M.; Fayad, Zahi A.; Farokhzad, Omid C.; Kim, YongTae; Langer, Robert | en_US |
| dspace.embargo.terms | N | en_US |
| dc.identifier.orcid | https://orcid.org/0000-0002-1263-1358 | |
| dc.identifier.orcid | https://orcid.org/0000-0002-6910-1905 | |
| dc.identifier.orcid | https://orcid.org/0000-0001-6031-7964 | |
| dc.identifier.orcid | https://orcid.org/0000-0003-4255-0492 | |
| mit.license | PUBLISHER_CC | en_US |
