dc.contributor.author | Arnold Anteraper, Sheeba | |
dc.contributor.author | Patil, Kaustubh R. | |
dc.contributor.author | Semwal, Meha | |
dc.contributor.author | Goldin, Rachel L. | |
dc.contributor.author | Furtak, Stephannie L. | |
dc.contributor.author | Chai, Xiaoqian Jenny | |
dc.contributor.author | Saygin, Zeynep M. | |
dc.contributor.author | Biederman, Joseph | |
dc.contributor.author | Joshi, Gagan | |
dc.contributor.author | Gabrieli, John D. E. | |
dc.contributor.author | Whitfield-Gabrieli, Susan | |
dc.date.accessioned | 2018-12-05T15:29:56Z | |
dc.date.available | 2018-12-05T15:29:56Z | |
dc.date.issued | 2017-11 | |
dc.identifier.issn | 2158-0014 | |
dc.identifier.issn | 2158-0022 | |
dc.identifier.uri | http://hdl.handle.net/1721.1/119442 | |
dc.description.abstract | The aim of this study is to assess the resting-state functional connectivity (RsFc) profile of the default mode network (DMN) in transition-age males with autism spectrum disorder (ASD). Resting-state blood oxygen level-dependent functional magnetic resonance imaging data were acquired from adolescent and young adult males with high-functioning ASD (n = 15) and from age-, sex-, and intelligence quotient-matched healthy controls (HCs; n = 16). The DMN was examined by assessing the positive and negative RsFc correlations of an average of the literature-based conceptualized major DMN nodes (medial prefrontal cortex [mPFC], posterior cingulate cortex, bilateral angular, and inferior temporal gyrus regions). RsFc data analysis was performed using a seed-driven approach. ASD was characterized by an altered pattern of RsFc in the DMN. The ASD group exhibited a weaker pattern of intra- and extra-DMN-positive and -negative RsFc correlations, respectively. In ASD, the strength of intra-DMN coupling was significantly reduced with the mPFC and the bilateral angular gyrus regions. In addition, the polarity of the extra-DMN correlation with the right hemispheric task-positive regions of fusiform gyrus and supramarginal gyrus was reversed from typically negative to positive in the ASD group. A wide variability was observed in the presentation of the RsFc profile of the DMN in both HC and ASD groups that revealed a distinct pattern of subgrouping using pattern recognition analyses. These findings imply that the functional architecture profile of the DMN is altered in ASD with weaker than expected integration and segregation of DMN RsFc. Future studies with larger sample sizes are warranted. Keywords: autism spectrum disorder; default mode network; resting-state fMRI | en_US |
dc.description.sponsorship | National Institute of Mental Health (U.S.) (Grant K23MH100450) | en_US |
dc.publisher | Mary Ann Liebert Inc | en_US |
dc.relation.isversionof | http://dx.doi.org/10.1089/BRAIN.2016.0483 | en_US |
dc.rights | Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. | en_US |
dc.source | Mary Ann Liebert | en_US |
dc.title | Integration and Segregation of Default Mode Network Resting-State Functional Connectivity in Transition-Age Males with High-Functioning Autism Spectrum Disorder: A Proof-of-Concept Study | en_US |
dc.type | Article | en_US |
dc.identifier.citation | Joshi, Gagan et al. “Integration and Segregation of Default Mode Network Resting-State Functional Connectivity in Transition-Age Males with High-Functioning Autism Spectrum Disorder: A Proof-of-Concept Study.” Brain Connectivity 7, 9 (November 2017): 558–573 © 2017 Mary Ann Liebert Inc | en_US |
dc.contributor.department | Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences | en_US |
dc.contributor.department | McGovern Institute for Brain Research at MIT | en_US |
dc.contributor.mitauthor | Joshi, Gagan | |
dc.contributor.mitauthor | Gabrieli, John D. E. | |
dc.contributor.mitauthor | Whitfield-Gabrieli, Susan | |
dc.relation.journal | Brain Connectivity | en_US |
dc.eprint.version | Final published version | en_US |
dc.type.uri | http://purl.org/eprint/type/JournalArticle | en_US |
eprint.status | http://purl.org/eprint/status/PeerReviewed | en_US |
dc.date.updated | 2018-12-03T20:18:55Z | |
dspace.orderedauthors | Joshi, Gagan; Arnold Anteraper, Sheeba; Patil, Kaustubh R.; Semwal, Meha; Goldin, Rachel L.; Furtak, Stephannie L.; Chai, Xiaoqian Jenny; Saygin, Zeynep M.; Gabrieli, John D.E.; Biederman, Joseph; Whitfield-Gabrieli, Susan | en_US |
dspace.embargo.terms | N | en_US |
dc.identifier.orcid | https://orcid.org/0000-0002-4373-7569 | |
dc.identifier.orcid | https://orcid.org/0000-0003-1158-5692 | |
mit.license | PUBLISHER_POLICY | en_US |