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dc.contributor.authorArnold Anteraper, Sheeba
dc.contributor.authorPatil, Kaustubh R.
dc.contributor.authorSemwal, Meha
dc.contributor.authorGoldin, Rachel L.
dc.contributor.authorFurtak, Stephannie L.
dc.contributor.authorChai, Xiaoqian Jenny
dc.contributor.authorSaygin, Zeynep M.
dc.contributor.authorBiederman, Joseph
dc.contributor.authorJoshi, Gagan
dc.contributor.authorGabrieli, John D. E.
dc.contributor.authorWhitfield-Gabrieli, Susan
dc.date.accessioned2018-12-05T15:29:56Z
dc.date.available2018-12-05T15:29:56Z
dc.date.issued2017-11
dc.identifier.issn2158-0014
dc.identifier.issn2158-0022
dc.identifier.urihttp://hdl.handle.net/1721.1/119442
dc.description.abstractThe aim of this study is to assess the resting-state functional connectivity (RsFc) profile of the default mode network (DMN) in transition-age males with autism spectrum disorder (ASD). Resting-state blood oxygen level-dependent functional magnetic resonance imaging data were acquired from adolescent and young adult males with high-functioning ASD (n = 15) and from age-, sex-, and intelligence quotient-matched healthy controls (HCs; n = 16). The DMN was examined by assessing the positive and negative RsFc correlations of an average of the literature-based conceptualized major DMN nodes (medial prefrontal cortex [mPFC], posterior cingulate cortex, bilateral angular, and inferior temporal gyrus regions). RsFc data analysis was performed using a seed-driven approach. ASD was characterized by an altered pattern of RsFc in the DMN. The ASD group exhibited a weaker pattern of intra- and extra-DMN-positive and -negative RsFc correlations, respectively. In ASD, the strength of intra-DMN coupling was significantly reduced with the mPFC and the bilateral angular gyrus regions. In addition, the polarity of the extra-DMN correlation with the right hemispheric task-positive regions of fusiform gyrus and supramarginal gyrus was reversed from typically negative to positive in the ASD group. A wide variability was observed in the presentation of the RsFc profile of the DMN in both HC and ASD groups that revealed a distinct pattern of subgrouping using pattern recognition analyses. These findings imply that the functional architecture profile of the DMN is altered in ASD with weaker than expected integration and segregation of DMN RsFc. Future studies with larger sample sizes are warranted. Keywords: autism spectrum disorder; default mode network; resting-state fMRIen_US
dc.description.sponsorshipNational Institute of Mental Health (U.S.) (Grant K23MH100450)en_US
dc.publisherMary Ann Liebert Incen_US
dc.relation.isversionofhttp://dx.doi.org/10.1089/BRAIN.2016.0483en_US
dc.rightsArticle is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use.en_US
dc.sourceMary Ann Lieberten_US
dc.titleIntegration and Segregation of Default Mode Network Resting-State Functional Connectivity in Transition-Age Males with High-Functioning Autism Spectrum Disorder: A Proof-of-Concept Studyen_US
dc.typeArticleen_US
dc.identifier.citationJoshi, Gagan et al. “Integration and Segregation of Default Mode Network Resting-State Functional Connectivity in Transition-Age Males with High-Functioning Autism Spectrum Disorder: A Proof-of-Concept Study.” Brain Connectivity 7, 9 (November 2017): 558–573 © 2017 Mary Ann Liebert Incen_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Brain and Cognitive Sciencesen_US
dc.contributor.departmentMcGovern Institute for Brain Research at MITen_US
dc.contributor.mitauthorJoshi, Gagan
dc.contributor.mitauthorGabrieli, John D. E.
dc.contributor.mitauthorWhitfield-Gabrieli, Susan
dc.relation.journalBrain Connectivityen_US
dc.eprint.versionFinal published versionen_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-12-03T20:18:55Z
dspace.orderedauthorsJoshi, Gagan; Arnold Anteraper, Sheeba; Patil, Kaustubh R.; Semwal, Meha; Goldin, Rachel L.; Furtak, Stephannie L.; Chai, Xiaoqian Jenny; Saygin, Zeynep M.; Gabrieli, John D.E.; Biederman, Joseph; Whitfield-Gabrieli, Susanen_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0002-4373-7569
dc.identifier.orcidhttps://orcid.org/0000-0003-1158-5692
mit.licensePUBLISHER_POLICYen_US


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