Impact of the physical microenvironment on tumor progression and metastasis
Author(s)Reynolds, Daniel S; Zaman, Muhammad H; Spill, Fabian; Kamm, Roger Dale
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The tumor microenvironment is increasingly understood to contribute to cancer development and progression by affecting the complex interplay of genetic and epigenetic changes within the cells themselves. Moreover, recent research has highlighted that, besides biochemical cues from the microenvironment, physical cues can also greatly alter cellular behavior such as proliferation, cancer stem cell properties, and metastatic potential. Whereas initial assays have focused on basic ECM physical properties, such as stiffness, novel in vitro systems are becoming increasingly sophisticated in differentiating between distinct physical cues — ECM pore size, fiber alignment, and molecular composition — and elucidating the different roles these properties play in driving tumor progression and metastasis. Combined with advances in our understanding of the mechanisms responsible for how cells sense these properties, a new appreciation for the role of mechanics in cancer is emerging.
DepartmentMassachusetts Institute of Technology. Department of Mechanical Engineering
Current Opinion in Biotechnology
Spill, Fabian et al. “Impact of the Physical Microenvironment on Tumor Progression and Metastasis.” Current Opinion in Biotechnology 40 (August 2016): 41–48 © 2016 Elsevier Ltd
Author's final manuscript