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Mechanistic studies of the anticancer activity of an octahedral hexanuclear Pt(II) cage

dc.contributor.authorZheng, Yaorong
dc.contributor.authorSuntharalingam, Kogularamanan
dc.contributor.authorBruno, Peter Michael
dc.contributor.authorLin, Wei
dc.contributor.authorWang, Weixue
dc.contributor.authorHemann, Michael
dc.contributor.authorLippard, Stephen J.
dc.date.accessioned2018-12-13T15:49:47Z
dc.date.available2018-12-13T15:49:47Z
dc.date.issued2016-03
dc.date.submitted2016-03
dc.identifier.issn0020-1693
dc.identifier.urihttp://hdl.handle.net/1721.1/119635
dc.description.abstractThe cellular response evoked by a hexanuclear platinum complex, Pt6L4(1), is reported. Compound 1, a 3-nm octahedral cage formed by self-assembly of six Pt(II) centers and four 2,4,6-tris(4-pyridyl)-1,3,5-triazine ligands (L), exhibits promising in vitro potency against a panel of human cancer cell lines. Unlike classical platinum-based anticancer agents, 1 interacts with DNA in a non-covalent, intercalative manner and promotes DNA condensation. In cancer cells, 1 induces DNA damage, upregulates p53, its phosphorylated form phospho-p53 and its downstream effector, p21, as well as both apoptosis and senescence. Keywords: Self-assembly; Cage; Anticancer; DNA damageen_US
dc.description.sponsorshipNational Cancer Institute (U.S.) (Grant CA034992)en_US
dc.publisherElsevieren_US
dc.relation.isversionofhttp://dx.doi.org/10.1016/J.ICA.2016.03.021en_US
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs Licenseen_US
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.sourcePMCen_US
dc.titleMechanistic studies of the anticancer activity of an octahedral hexanuclear Pt(II) cageen_US
dc.typeArticleen_US
dc.identifier.citationZheng, Yao-Rong et al. “Mechanistic Studies of the Anticancer Activity of an Octahedral Hexanuclear Pt(II) Cage.” Inorganica Chimica Acta 452 (October 2016): 125–129 © 2016 Elsevier B.V.en_US
dc.contributor.departmentMassachusetts Institute of Technology. Department of Chemistryen_US
dc.contributor.departmentKoch Institute for Integrative Cancer Research at MITen_US
dc.contributor.mitauthorZheng, Yaorong
dc.contributor.mitauthorSuntharalingam, Kogularamanan
dc.contributor.mitauthorBruno, Peter Michael
dc.contributor.mitauthorLin, Wei
dc.contributor.mitauthorWang, Weixue
dc.contributor.mitauthorHemann, Michael
dc.contributor.mitauthorLippard, Stephen J.
dc.relation.journalInorganica Chimica Actaen_US
dc.eprint.versionAuthor's final manuscripten_US
dc.type.urihttp://purl.org/eprint/type/JournalArticleen_US
eprint.statushttp://purl.org/eprint/status/PeerRevieweden_US
dc.date.updated2018-12-04T14:10:51Z
dspace.orderedauthorsZheng, Yao-Rong; Suntharalingam, Kogularamanan; Bruno, Peter M.; Lin, Wei; Wang, Weixue; Hemann, Michael T.; Lippard, Stephen J.en_US
dspace.embargo.termsNen_US
dc.identifier.orcidhttps://orcid.org/0000-0003-3383-0118
dc.identifier.orcidhttps://orcid.org/0000-0002-2693-4982
mit.licensePUBLISHER_CCen_US


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